Bioactive keratin peptides

ABSTRACT

Compositions containing biologically active peptides are disclosed. Active peptides are isolated fragments derived from human hair or sheep wool keratin proteins. Compositions may be prepared for pharmaceutical or topical administration or for use in cosmetic preparations.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a divisional of U.S. Ser. No. 10/352,786, filed Jan. 28, 2003, now U.S. Pat. No. 7,501,485, and claims benefit of priority of U.S. Provisional Application No. 60/352,396, filed Jan. 28, 2002, the disclosures of both of which are incorporated herein in their entirety by reference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

N/A

BACKGROUND OF THE INVENTION

Chronic wounds can be caused by a variety of events, including surgery, prolonged bedrest and traumatic injuries. Partial thickness wounds can include second degree burns, abrasions, and skin graft donor sites. Healing of these wounds can be problematic, especially in cases of diabetes mellitus or chronic immune disorders. Full thickness wounds have no skin remaining, and can be the result of trauma, diabetes (e.g., leg ulcers) and venous stasis disease, which can cause full thickness ulcers of the lower extremities. Full thickness wounds tend to heal very slowly or not at all. Proper wound care technique including the use of wound dressings is extremely important to successful chronic wound management. Chronic wounds affect an estimated four million people a year, resulting in health care costs in the billions of dollars. T. Phillips, O. Kehinde, and H. Green, “Treatment of Skin Ulcers with Cultivated Epidermal Allografts,” J. Am. Acad. Dermatol, V. 21, pp. 191-199 (1989).

The wound-healing process involves a complex series of biological interactions at the cellular level which can be grouped into three phases: homeostasis and inflammation; granulation tissue formation and reepithelization; and remodeling. R. A. F. Clark, “Cutaneous Tissue Repair: Basic Biological Considerations,” J. Am. Acad. Dermatol, Vol. 13, pp. 701-725 (1985). Keratinocytes (epidermal cells that manufacture and contain keratin) migrate from wound edges to cover the wound. Growth factors such as transforming growth factor-β (TGF-β) play a critical role in stimulating the migration process. The migration occurs optimally under the cover of a moist layer. Keratins have also been found to be necessary for reepithelization. Specifically, keratin types K5 and K14 have been found in the lower, generating, epidermal cells, and types K1 and K10 have been found in the upper, differentiated cells. I. K. Cohen, R. F. Diegleman, and W. J. Lindblad, eds., Wound Healing: Biochemical and Clinical Aspects, W.W. Saunders Company, 1992. Keratin types K6 and K10 are believed to be present in healing wounds, but not in normal skin. Keratins are major structural proteins of all epithelial cell types and appear to play a major role in wound healing.

Although not ideal for chronic wounds, several wound dressings are currently on the market, including occlusive dressings, non-adherent dressings, absorbent dressings, and dressings in the form of sheets, foams, powders and gels. S. Thomas, Wound Management and Dressing, The Pharmaceutical Press, London, 1990.

Attempts have been made to provide improved dressings that would assist in the wound-healing process using biological materials such as growth factors. These biologicals have proven very costly and, due to the lack of an appropriate delivery vehicle, have shown minimal clinical relevance in accelerating the chronic wound-healing process relative to their cost. In cases of severe full thickness wounds, autografts (skin grafts from the patient's body) are often used. Although the graft is non-antigenic, it must be harvested from a donor site on the patient's body, creating an additional wound. In addition, availability of autologous tissue may not be adequate. Allografts (skin grafts from donors other than the patient) are also used when donor sites are not an option. Allografts essentially provide a “wound dressing” that provides a moist, water-permeable layer, but are rejected by the patient, usually within two weeks, and do not become part of the new epidermis.

SUMMARY

The present disclosure arises from the surprising discovery that certain peptides derived from keratin proteins exhibit biological activity. The activity of these peptides has been demonstrated by their ability to stimulate growth of dermal fibroblasts comparable with known fibroblast growth factors. Compositions containing the peptides are thus useful in the treatment of conditions involving damaged, aged, or diseased epithelial tissue and skin. Because of the cytokine-like activity of the peptides, compositions containing these peptides are also contemplated to be useful in stimulation of tissue or cell growth in applications including, but not limited to tissue growth and repair including skin and bone tissue. The amino acid sequences of the active peptides indicate that the peptides are derived from a region of 39 amino acids that appears in various human hair and sheep wool keratin proteins. This conserved segment contains single amino acid changes in several locations in the consensus. The claimed compositions include peptides of from 4 to 39 amino acids in length that incorporate each of the sequence variations.

The present disclosure may be described therefore, in a preferred embodiment, as a composition that includes one or more biologically active peptides and in which the peptides are from about 4 to about 39 amino acids in length and occur as contiguous sequences in the peptides disclosed herein as SEQ ID NOs:1-32. The peptides may be made by any means known in the art, including isolation from natural sources, recombinant production or chemical synthesis. Natural sources would include keratin proteins that naturally occur in inter alia, human hair, animal hair, wool, fur, nails, hooves, horns, beaks, skin and feathers. Recombinantly produced peptides may also be expressed in a bacterial host cell or a eukaryotic host cell.

An alternative embodiment of the present disclosure is an isolated nucleic acid molecule that encodes any of the peptides disclosed herein and described in the previous paragraph, and more specifically, an isolated nucleic acid molecule that encodes any peptide of from about 4 to about 39 amino acids that occurs as a contiguous amino acid sequence in the peptides designated herein as SEQ ID NOs:1-32. Such peptides include all the peptides disclosed herein as SEQ ID NOS:1-4469, inclusively. The isolated nucleic acid sequences or molecules may be fragments of naturally occurring nucleic acid sequences that encode keratin proteins, for example, or they may be variations of such sequences that encode the disclosed peptides due to redundancies in the genetic code. Alternatively, the nucleic acid molecules may be chemically synthesized based on the desired amino acid sequences to be expressed. The isolated nucleic acid sequences or molecules are preferably contained in vectors, including expression vectors capable of directing expression of the peptides in an appropriate host cell. The host cell may preferably be a bacterial cell or a eukaryotic cell. Certain embodiments of the present disclosure are vectors containing the described nucleic acid segments and host cells that contain those vectors.

In certain embodiments of the disclosure, the peptides are contained in, or combined with pharmaceutically acceptable carriers. As used herein, “pharmaceutically acceptable carrier” includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the peptide ingredients, its use in the therapeutic or cosmetic compositions is contemplated.

The pharmaceutical compositions are preferably formulated for administration to veterinary or human subjects, and may be optionally formulated for oral, topical or optical administration. Similarly, the claimed compositions may be formulated for implantation, coated on a surface to be implanted or contained within an implant. Additionally, in certain preferred embodiments, the compositions are formulated for application to wounds. In certain embodiments, the claimed compositions are formulated for application to burned, aged, wrinkled, scarred, or damaged skin, and are also useful in the relief of pain, burning, or itching. In certain embodiments, the peptide containing compositions of the present disclosure are formulated for the treatment of gastrointestinal, anal, vaginal, ear, eye, lung, nasal, oral or urogenital epithelial tissue, including, but not limited to, for example, the treatment of Crohn's disease, skin grafts or ulcers, including diabetic ulcers.

The biological activity of the disclosed peptides may be any activity that is beneficial as a research tool for or for the benefit of a human or animal recipient of the formulations, including cell growth activation or inhibition, or cytokine-like activity. The cytokine-like activity is preferably cell differentiation, cell proliferation, cell adhesion, effect on cell morphology, cell migration, inflammatory response, angiogenesis; cell death or the like. The disclosed peptides may also be combined with other growth factors in order to enhance the healing activity of damaged skin, for example. In certain embodiments, then, a composition may contain any of the peptides derived from the peptides designated as SEQ ID NO:1-32 in combination with a growth factor such as epidermal growth factor (EGF), transforming growth factor-alpha (TGF-a), fibroblast growth factor (FGF), keratinocyte growth factor (KGF), platelet derived growth factor (PDGF) or a mixture of these in any combination.

An additional preferred embodiment of the present disclosure is compositions containing the described peptides in which the peptide or peptides are present in an amount effective to inhibit microbial growth. It has been observed by the present inventor that solutions containing the disclosed peptides may be kept “on the shelf” for extended periods of time without becoming contaminated with microbial growth. The compositions are contemplated, therefore, to be effective in inhibition of microbial contamination or growth.

In certain embodiments, the compositions of the present disclosure may be formulated as cosmetics. The cosmetic preparations may be in the form of a powder, lotion, hydrogel, oil, emulsion, paste; polish or cream. The cosmetics may optionally contain a coloring agent and/or a fragrance.

The compositions of the present disclosure may be used with benefit in virtually all categories of skin cosmetics for both women and men. These would include, but are not limited to preparations formulated as moisturizers, deodorants, anti-aging/skin repair preparations, cleansers and toners, eye care, lip care, fingernail or toenail care, scalp care, sun care, and hand and body preparations. Moreover, after-care products for such skin insults as chemical peels, sunburn, depilatory irritation, razor-shaving nicks and abrasions, scalp irritation from hair perming and straightening, and the like that include the disclosed peptides would fill a much needed void in the cosmetics arena. Many water-based make-up products may be fortified with the disclosed compositions to provide continuing skin therapy during their daily use. The disclosed peptide compositions will also find use in hair care products, such as shampoo, for example. Because of the benefits to skin, shampoos and conditioners are contemplated to be an effective way to deliver the peptides to the scalp.

Compositions including the peptides disclosed herein may also include a cell or tissue growth scaffold. The tissue growth scaffold may preferably be defined as a spinal implant, bone growth scaffold, scaffold for growth of epithelial tissue, a bandage, a non-woven sheet or a woven sheet. It may also be preferable for the non-woven or woven sheets to be keratin derived or to contain natural keratins, including, but not limited to wool pads, woven keratin, keratin bonded to polymer sheets, or cross-linked keratin. Additionally, the tissue growth scaffold may include an envelope containing the peptides or peptides coated or bonded to the surface of a metal, silicone or polymer implant.

DETAILED DESCRIPTION

The present disclosure provides a new family of biologically active peptides derived from plentiful and renewable resources. In a significant number of in vitro cell-culture studies, the present inventor has shown that the cell proliferation activity of the keratin-derived peptides mimic most all of the known growth factors, including FGF, KGF, EGF, and PDGF. In vivo studies in animals have shown that these peptides are potent anti-irritants and that they promote and/or accelerate wound healing. Moreover, these peptides, when applied topically to human volunteers, significantly restore skin barrier properties and rejuvenate aged skin. Based on these early findings, it is concluded that these keratin-derived peptides are “potent” cellular activators effecting both cell proliferation and cell differentiation in mammals, and that they have multiple uses in the medical and cosmetics arenas.

When isolated from natural sources such as human hair or wool, the biologically active peptides can yield one or several soluble peptide fractions from each raw material. These fractions appear to differ from each other mostly in their average molecular weight and their acid solubility. All fractions are readily soluble in the near-neutral pH range used for most cosmetics formulary. In cell culture studies with human fibroblasts, peptide preparations exhibited significant activation of cell proliferation at a concentration of from 100 to 0.001 μg/mL. Based on the data and the activities of known bioactive peptides, it is contemplated that the peptide compositions are active in the range of from 0.0001 to 0.00001 μg/mL. Although the specific cosmetic formulations may affect the delivery of these peptides to and/or through the skin, this in vitro cell-culture result suggests that a useful concentration of the peptides for cell activation could be less than 1%, or less than 0.4%, less than 0.1%, less than 0.01% or even less than 0.001%.

In addition to the in vitro and in vivo studies mentioned above, addition anecdotal information has been gathered regarding the disclosed peptides when opportunities for human experimentation were available. From these studies, it is contemplated that the peptide compositions are both anti-inflammatory and anti-microbial and that they mediate pain at wound-healing sites. Moreover, application of the peptide compositions to skin burns, including chemical burns and sunburn, expedites healing and minimizes discomfort.

The present disclosure arises from the surprising discovery that certain peptide fragments disclosed herein have beneficial biological activities, primarily demonstrated in in vitro studies by their effect on the growth of certain types of biological cells, and particularly dermal fibroblast cells. Because of the ability of certain of the disclosed peptide containing compositions to stimulate or to inhibit growth of fibroblast cells, the compositions find particular utility in applications that involve healing of aging, damage or pathologies of epithelial or connective tissues.

The cytokine-like properties of the peptide compositions can be used to promote healing, repair, and cell growth in keratinous tissue generally. The peptides can be used to treat damaged skin and skin wounds including, for example, rashes, including diaper rash, burns including sunburn, cuts, abrasions, punctures, sores including bed sores, ulcers including diabetic ulcers and other skin injuries or irritations. The peptide compositions can also be used to treat aging, weakened or damaged skin, including, for example, wrinkled skin. Particular applications include the treatment of damaged tissue in the external skin, or epidermal layers, in oral, pulmonary, gastro-intestinal, or spinal tissues.

The peptide containing compositions may be formulated as a powder, lotion, hydrogel, oil, emulsion, paste, cream, or gel for application to the skin or gums, or it may be formulated as an aerosol, an implant, an implant coating or a scaffolding material for tissue growth. For example, the peptide compositions may be contained in a woven or non-woven sheet material, or adsorbed in a hydrogel, or in a hydrogel contained in a biocompatible envelope material.

Preparation of Peptides

In certain embodiments the disclosed peptides may be isolated from naturally occurring sources such as human hair or sheep wool, for example. Preferred methods of preparing a small sample composition containing the claimed peptides follows. It is understood, of course, that this preparation may be made at a much larger scale in order to obtain larger, commercial quantities of the composition.

General methods of producing the peptide containing compositions from a keratin substrate include oxidizing the keratin substrate with an oxidizing agent, to substantially break the disulfide bonds that make keratins insoluble and inert. Examples of oxidizing agents that can be used include, but are not limited to, hydrogen peroxide, peracetic acid, percarbonates, persulfates, chlorine dioxide, sodium and calcium peroxides, perborates, and hypochlorite. The oxidized hair is filtered, the filtrate collected, and neutralized with base. Water soluble peptides from the neutralized filtrate may be precipitated from solution by mixing the filtrate with a water-miscible organic solvent such as methanol. Alternatively the oxidized keratin may be partially or totally dissolved in dilute aqueous alkali, filtered to remove solids, and the filtrate may be precipitated by acidification or by adding a miscible non-solvent such as ethanol or methanol, to obtain a greater fraction of the keratin material. The precipitate is collected with filtration and the collected filtrate is dried.

A more specific protocol follows:

Hot Method

-   -   Weigh 100 g of washed cut-up keratin substrate (hair, scoured         unbleached, or un-dyed wool, ˜0.25-0.5 inches in length) into a         3 L RB flask containing a stirring assembly and gas adaptor     -   Add 1565 mL of distilled, de-ionized (DI) H₂O     -   Add 110 mL of 30% H₂O₂     -   Heat to reflux with stirring     -   Stir at reflux for ˜2 hours     -   Remove heating mantle     -   Continue to stir and cool to <50° C. allow to settle and filter         using Buchner funnel and fast filter paper.     -   Rinse filtrate twice with 250 mL hot (˜50° C.) DI H₂O     -   Save oxidized keratin filtrant (Intermediate A) for further         processing later     -   Allow filtrate to cool to ˜room temperature     -   Neutralize filtrate to pH=7.0±0.2 with ˜3N NH₄OH     -   Concentrate with aspirator vacuum to ˜165 mL.     -   Cool to about freezing     -   Precipitate into 1 L of freezer-cold MeOH     -   Filter immediately in Buchner funnel with medium-fast filter         paper, washing filtrant with 2-250 mL portions of freezer cold         MeOH

Alternatively:

-   -   Store entire mixture overnight in freezer allowing precipitate         to settle     -   Decant excess MeOH     -   Filter remaining mixture in Buchner funnel with medium-fast         filter paper, washing filtrant with 2-250 mL portions of freezer         cold MeOH     -   Dry filtrant on filter paper overnight in a vacuum oven     -   Carefully scrape dried material from filter paper into mortar         and grind if necessary with a pestle     -   Weigh product into a labeled glass jar with a Teflon-lined cap,         record % SKP (soluble keratin peptide) yield based on keratin         substrate, and store product at room temperature.

Enhanced Peptide Yields

-   -   Put oxidized keratin filtrant (Intermediate A from Hot Process         above) in a 5-L beaker, add 4 L of 0.1 N ammonium hydroxide and         stir for 24 hr at room temperature.     -   Filter solution and discard filtrant.     -   To filtrate, add glacial acetic acid dropwise with constant         stirring to pH 4 causing acid-insoluble peptides to precipitate.         Filter with Buchner funnel and save filtrate (acid soluble gamma         fraction).     -   Wash filtrant (acid-insoluble alpha fraction) with 1 L of water         and reject washings. Redissolve filtrant in 2 L of 0.01 N         ammonium hydroxide and add this solution with constant stirring         to 4 L of ethanol containing 10 mL of acetic acid. Filter with         Buchner funnel and discard filtrate.     -   Wash filtrant with 1 L of ethanol and dry filtrant (alpha         peptides) in a warm vacuum oven.     -   Carefully scrape dried material from filter paper and store in a         glass jar labeled “alpha peptide”.     -   Take acid-soluble gamma filtrate from the first step, and         concentrate it in vacuo to about 200 mL. Pour concentrate into 2         L of ethanol with constant stirring to precipitate gamma         peptides.     -   Recover gamma peptides by filtration with a Buchner funnel and         discard filtrate.     -   Suspend filtrant in 1 L of ethanol and stir for 2 hr to dissolve         residual ammonium acetate. Filter with Buchner funnel, discard         filtrant, and dry filtrant in a warm vacuum oven.     -   Carefully scrape dried material from filter paper and store in a         glass jar labeled “gamma peptide”.

In certain embodiments, the peptides in the disclosed compositions may be chemically synthesized by methods well known in the art. Solid phase peptide synthesis involves a stepwise assembly of a peptide chain while anchored to a support or solid phase peptide resin. There are two generally well-known methods of the solid phase synthesis of peptides.

The first, known as the Merrifield method, utilizes a solid support or resin which holds the C-terminal amino acid by the carboxyl group as the peptide is being synthesized through the attachment of amino acid or peptide residues as building blocks. The N-terminus of the resin-bound peptide is deblocked and N-protected amino acids are added, usually with a coupling agent. Activating agents may be used to improve rate and selectivity. After the peptide bond is formed, the protected group is removed and the cycle is repeated, if desired, until all the amino acids have been added to the peptide in the desired order.

The second method of chemical synthesis is the “polymeric reagent synthesis”, also known as the “inverse Merrifield” method. This technique involves reagents bound to solid supports in a series of columns and passing the amino acid or peptide residues through the columns to form the peptide or amino acid sequence.

In certain embodiments, the peptides may be produced recombinantly from isolated nucleic acid molecules that encode the disclosed peptides. For example, the present disclosure provides recombinant cloning and expression vectors containing DNA, as well as host cells containing the recombinant vectors. Expression vectors comprising DNA may be used to prepare the disclosed peptides encoded by the DNA. A method for producing peptides comprises culturing host cells transformed with a recombinant expression vector encoding the peptide, under conditions that promote expression of the peptide, then recovering the expressed peptides from the culture. The skilled artisan will recognize that the procedure for purifying the expressed peptides will vary according to such factors as the type of host cells employed, and the level of purity required for the particular preparation. It is understood that the peptide compositions of the present invention can be of any useful purity, including crude extracts of cell or tissue culture.

Any suitable expression system may be employed. The vectors include a DNA encoding a peptide of the invention, operably linked to suitable transcriptional or translational regulatory nucleotide sequences, such as those derived from a mammalian, microbial, viral, or insect gene. Examples of regulatory sequences include transcriptional promoters, operators, or enhancers, an mRNA ribosomal binding site, and appropriate sequences which control transcription and translation initiation and termination. Nucleotide sequences are operably linked when the regulatory sequence functionally relates to the DNA sequence. Thus, a promoter nucleotide sequence is operably linked to a DNA sequence if the promoter nucleotide sequence controls the transcription of the DNA sequence. An origin of replication that confers the ability to replicate in the desired host cells, and a selection gene by which transformants are identified, are generally incorporated into the expression vector.

In addition, a sequence encoding an appropriate signal peptide (native or heterologous) can be incorporated into expression vectors. A DNA sequence for a signal peptide (secretory leader) may be fused in frame to the nucleic acid sequence of the invention so that the DNA is initially transcribed, and the mRNA translated, into a fusion protein comprising the signal peptide. A signal peptide that is functional in the intended host cells promotes extracellular secretion of the peptide. The signal peptide is cleaved from the peptide upon secretion of peptide from the cell.

Suitable host cells for expression of peptides include prokaryotes, yeast or higher eukaryotic cells. Prokaryotic host cells, such as bacterial cells are generally preferred for use as host cells. Appropriate cloning and expression vectors for use with bacterial, fungal, yeast, and mammalian cellular hosts are described, for example, in Pouwels et al. Cloning Vectors: A Laboratory Manual, Elsevier, N.Y., (1985). Cell-free translation systems could also be employed to produce peptides using RNAs derived from DNA constructs disclosed herein.

Prokaryotes include gram-negative or gram-positive organisms. Suitable prokaryotic host cells for transformation include, for example, E. coli, Bacillus subtilis, Salmonella typhimurium, and various other species within the genera Pseudomonas, Streptomyces, and Staphylococcus. In a prokaryotic host cell, such as E. coli, a peptide may include an N-terminal methionine residue to facilitate expression of the recombinant peptide in the prokaryotic host cell. The N-terminal Met may be cleaved from the expressed recombinant peptide.

Expression vectors for use in prokaryotic host cells generally comprise one or more phenotypic selectable marker genes. A phenotypic selectable marker gene is, for example, a gene encoding a protein that confers antibiotic resistance or that supplies an autotrophic requirement. Examples of useful expression vectors for prokaryotic host cells include those derived from commercially available plasmids such as the cloning vector pBR322 (ATCC 37017). pBR322 contains genes for ampicillin and tetracycline resistance and thus provides simple means for identifying transformed cells. An appropriate promoter and a DNA sequence are inserted into the pBR322 vector. Other commercially available vectors include, for example, pKK223-3 (Pharmacia Fine Chemicals, Uppsala, Sweden) and pGEM1 (Promega Biotec, Madison, Wis., USA).

Promoter sequences commonly used for recombinant prokaryotic host cell expression vectors include β-lactamase (penicillinase), lactose promoter system (Chang et al., Nature 275:615, 1978; and Goeddel et al., Nature 281:544, 1979), tryptophan (trp) promoter system (Goeddel et al., Nucl. Acids Res. 8:4057, 1980; and EP-A-36776) and tac promoter (Maniatis, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, p. 412, 1982). A particularly useful prokaryotic host cell expression system employs a phage λP_(L) promoter and a cI857ts thermolabile repressor sequence. Plasmid vectors available from the American Type Culture Collection which incorporate derivatives of the λP_(L) promoter include plasmid pHUB2 (resident in E. coli strain JMB9, ATCC 37092) and pPLc28 (resident in E. coli RR1, ATCC 53082).

Alternatively, the peptides may be expressed in yeast host cells, preferably from the Saccharomyces genus (e.g., S. cerevisiae). Other genera of yeast, such as Pichia or Kluyveromyces, may also be employed. Yeast vectors will often contain an origin of replication sequence from a 2μ yeast plasmid, an autonomously replicating sequence (ARS), a promoter region, sequences for polyadenylation, sequences for transcription termination, and a selectable marker gene. Suitable promoter sequences for yeast vectors include, among others, promoters for metallothionein, 3-phosphoglycerate kinase (Hitzeman et al., J. Biol. Chem. 255:2073, 1980) or other glycolytic enzymes (Hess et al., J. Adv. Enzyme Reg. 7:149, 1968; and Holland et al., Biochem. 17:4900, 1978), such as enolase, glyceraldehyde-3-phosphate dehydrogenase, hexokinase, pyruvate decarboxylase, phosphofructokinase, glucose-6-phosphate isomerase, 3-phosphoglycerate mutase, pyruvate kinase, triosephosphate isomerase, phospho-glucose isomerase, and glucokinase. Other suitable vectors and promoters for use in yeast expression are further described in Hitzeman, EPA-73,657. Another alternative is the glucose-repressible ADH2 promoter described by Russell et al. (J. Biol. Chem. 258:2674, 1982) and Beier et al. (Nature 300:724, 1982). Shuttle vectors replicable in both yeast and E. coli may be constructed by inserting DNA sequences from pBR322 for selection and replication in E. coli (Amp^(r) gene and origin of replication) into the above-described yeast vectors.

The yeast α-factor leader sequence may be employed to direct secretion of the peptide. The α-factor leader sequence is often inserted between the promoter sequence and the structural gene sequence. See, e.g., Kurjan et al., Cell 30:933, 1982 and Bitter et al., Proc. Natl. Acad. Sci. USA 81:5330, 1984. Other leader sequences suitable for facilitating secretion of recombinant peptides from yeast hosts are known to those of skill in the art. A leader sequence may be modified near its 3′ end to contain one or more restriction sites. This will facilitate fusion of the leader sequence to the structural gene.

Yeast transformation protocols are known to those of skill in the art. One such protocol is described by Hinnen et al., Proc. Natl. Acad. Sci. USA 75:1929, 1978. The Hinnen et al. protocol selects for Trp⁺ transformants in a selective medium, wherein the selective medium consists of 0.67% yeast nitrogen base, 0.5% casamino acids, 2% glucose, 10 mg/ml adenine and 20 mg/ml uracil.

Yeast host cells transformed by vectors containing an ADH2 promoter sequence may be grown for inducing expression in a “rich” medium. An example of a rich medium is one consisting of 1% yeast extract, 2% peptone, and 1% glucose supplemented with 80 mg/ml adenine and 80 mg/ml uracil. Derepression of the ADH2 promoter occurs when glucose is exhausted from the medium.

Mammalian or insect host cell culture systems also may be employed to express recombinant peptides. Bacculovirus systems for production of heterologous proteins in insect cells are reviewed by Luckow and Summers, Bio/Technology 6:47 (1988). Established cell lines of mammalian origin also may be employed. Examples of suitable mammalian host cell lines include the COS-7 line of monkey kidney cells (ATCC CRL 1651) (Gluzman et al., Cell 23:175, 1981), L cells, C127 cells, 3T3 cells (ATCC CCL 163), Chinese hamster ovary (CHO) cells, HeLa cells, and BHK (ATCC CRL 10) cell lines, and the CV1/EBNA cell line derived from the African green monkey kidney cell line CV1 (ATCC CCL 70) as described by McMahan et al. (EMBO J. 10: 2821, 1991).

Established methods for introducing DNA into mammalian cells have been described (Kaufman, R. J., Large Scale Mammalian Cell Culture, 1990, pp. 15-69). Additional protocols using commercially available reagents, such as Lipofectamine lipid reagent (Gibco/BRL) or Lipofectamine-Phis lipid reagent, can be used to transfect cells (Felgner et al., Proc. Natl. Acad. Sci. USA 84:7413-7417, 1987). In addition, electroporation can be used to transfect mammalian cells using conventional procedures, such as those in Sambrook et al. (Molecular Cloning: A Laboratory Manual, 2 ed. Vol. 1-3, Cold Spring Harbor Laboratory Press, 1989). Selection of stable transformants can be performed using methods known in the art, such as, for example, resistance to cytotoxic drugs. Kaufman et al., Meth. in Enzymology 185:487-511, 1990, describes several selection schemes, such as dihydrofolate reductase (DHFR) resistance. A suitable host strain for DHFR selection can be CHO strain DX-B11, which is deficient in DHFR (Urlaub and Chasin, Proc. Natl. Acad. Sci. USA 77:4216-4220, 1980). A plasmid expressing the DHFR cDNA can be introduced into strain DX-B11, and only cells that contain the plasmid can grow in the appropriate selective media. Other examples of selectable markers that can be incorporated into an expression vector include cDNAs conferring resistance to antibiotics, such as G418 and hygromycin B. Cells harboring the vector can be selected on the basis of resistance to these compounds.

Transcriptional and translational control sequences for mammalian host cell expression vectors can be excised from viral genomes. Commonly used promoter sequences and enhancer sequences are derived from polyoma virus, adenovirus 2, simian virus 40 (SV40), and human cytomegalovirus. DNA sequences derived from the SV40 viral genome, for example, SV40 origin, early and late promoter, enhancer, splice, and polyadenylation sites can be used to provide other genetic elements for expression of a structural gene sequence in a mammalian host cell. Viral early and late promoters are particularly useful because both are easily obtained from a viral genome as a fragment, which can also contain a viral origin of replication (Fiers et al., Nature 273:113, 1978; Kaufman, Meth. in Enzymology, 1990). Smaller or larger SV40 fragments can also be used, provided the approximately 250 by sequence extending from the Hind III site toward the Bgl I site located in the SV40 viral origin of replication site is included.

Additional control sequences shown to improve expression of heterologous genes from mammalian expression vectors include such elements as the expression augmenting sequence element (EASE) derived from CHO cells (Morris et al., Animal Cell Technology, 1997, pp. 529-534 and PCT Application WO 97/25420) and the tripartite leader (TPL) and VA gene RNAs from Adenovirus 2 (Gingeras et al., J. Biol. Chem. 257:13475-13491, 1982). The internal ribosome entry site (IRES) sequences of viral origin allows dicistronic mRNAs to be translated efficiently (Oh and Sarnow, Current Opinion in Genetics and Development 3:295-300, 1993; Ramesh et al., Nucleic Acids Research 24:2697-2700, 1996). Expression of a heterologous cDNA as part of a dicistronic mRNA followed by the gene for a selectable marker (e.g. DHFR) has been shown to improve transfectability of the host and expression of the heterologous cDNA (Kaufman, Meth. in Enzymology, 1990). Exemplary expression vectors that employ dicistronic mRNAs are pTR-DC/GFP described by Mosser et al., Biotechniques 22:150-161, 1997, and p2A5I described by Morris et al., Animal Cell Technology, 1997, pp. 529-534.

A useful high expression vector, pCAVNOT, has been described by Mosley et al., Cell 59:335-348, 1989. Other expression vectors for use in mammalian host cells can be constructed as disclosed by Okayama and Berg (Mol. Cell. Biol. 3:280, 1983). A useful system for stable high level expression of mammalian cDNAs in C127 murine mammary epithelial cells can be constructed substantially as described by Cosman et al. (Mol. Immunol. 23:935, 1986). A useful high expression vector, PMLSV N1/N4, described by Cosman et al., Nature 312:768, 1984, has been deposited as ATCC 39890. Additional useful mammalian expression vectors are described in EP-A-0367566, and in WO 91/18982, incorporated by reference herein. In yet another alternative, the vectors can be derived from retroviruses.

The disclosure also includes methods of isolating and purifying the peptides. The “isolated” peptides encompassed by this invention are peptides that are not in an environment identical to an environment in which they can be found in nature. The “purified” peptides or fragments thereof encompassed by this invention are essentially free of association with other proteins or polypeptides, for example, as a purification product of recombinant expression systems such as those described above or as a purified product from a non-recombinant source such as naturally occurring cells and/or tissues, or as peptides isolated from the native keratin proteins in which they occur.

In one preferred embodiment, the purification of recombinant peptides or fragments can be accomplished using fusions of peptides or fragments of the invention to another polypeptide to aid in the purification of peptides or fragments of the invention. Such fusion partners can include the poly-His or other antigenic identification peptides described above as well as the Fe moieties.

Pharmaceutical Compositions

Compositions comprising an effective amount of a peptide or combination of peptides of the present invention, in combination with other components such as a physiologically acceptable diluent, carrier, or excipient, are provided herein. The peptides can be formulated according to known methods used to prepare pharmaceutically useful compositions. They can be combined in admixture, either as the sole active material or with other known active materials suitable for a given indication, with pharmaceutically acceptable diluents (e.g., saline, Tris-HCl, acetate, and phosphate buffered solutions), preservatives (e.g., thimerosal, benzyl alcohol, parabens), emulsifiers, solubilizers, adjuvants and/or carriers. A peptide may be formulated into a composition in a neutral or salt form. Pharmaceutically acceptable salts, include the acid addition salts (formed with the free amino groups of the peptide) and which are formed with inorganic acids such as, for example, hydrochloric or phosphoric acids, or such organic acids as acetic, oxalic, tartaric, mandelic, and the like. Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium, or ferric hydroxides, and such organic bases as isopropylamine, trimethylamine, histidine, procaine and the like. The compositions disclosed herein may be formulated in any appropriate delivery vehicle, including, but not limited to hydrogels, lotions, aqueous solutions, non-aqueous solutions, non-woven mediums, woven mediums, tissue or cell growth scaffolds and powders. Suitable formulations for pharmaceutical compositions include those described in Remington's Pharmaceutical Sciences, 16th ed. 1980, Mack Publishing Company, Easton, Pa.

In addition, such compositions can be complexed with polyethylene glycol (PEG), metal ions, or incorporated into polymeric compounds such as polylactic acid, polyglycolic acid, hydrogels, dextran, etc., or incorporated into liposomes, microemulsions, micelles, unilamellar or multilamellar vesicles, erythrocyte ghosts or spheroblasts. Such compositions will influence the physical state, solubility, stability, rate of in vivo release, and rate of in vivo clearance, and are thus chosen according to the intended application.

The compositions of the invention can be administered in any suitable manner, e.g., topically, parenterally, or by inhalation. The term “parenteral” includes injection, e.g., by subcutaneous, intravenous, or intramuscular routes, also including localized administration, e.g., at a site of disease or injury. Sustained release from implants is also contemplated. One skilled in the pertinent art will recognize that suitable dosages will vary, depending upon such factors as the nature of the disorder to be treated, the patient's body weight, age, and general condition, and the route of administration. Preliminary doses can be determined according to animal tests, and the scaling of dosages for human administration is performed according to art-accepted practices.

In certain preferred embodiments of use, the peptide containing compositions may be formulated as a powder to be placed over a wound, for example. The peptide powder can also be formulated into any water-based solution, cream, gel, or other vehicle for convenient application to a wound. In addition, a peptide solution could be incorporated into or cast onto a polymer wound dressing or a keratin wound dressing sheet for application to a wound. In in vitro trials, compositions containing the disclosed peptides were shown to enhance proliferation of human skin keratinocytes, human dermal fibroblasts, and microvascular endothelial cells, thus demonstrating the efficacy of the peptides in wound-healing applications.

The peptides can also be added as a cell growth stimulant to a tissue engineering scaffold such as the sheet described in U.S. Pat. No. 6,110,487, incorporated herein by reference. The peptides are contemplated to speed repair of sun or weather damaged skin. The peptides may be mixed with a carrier lotion such as lanolin and applied to the skin. The peptides may also be added to cosmetics to impart a skin healing property to the cosmetic. Cosmetic bases are believed suitable for inclusion of peptides made according to the present invention.

In certain embodiments, the peptides compositions disclosed herein may be included in, attached to, or adhered to other products, including wound dressings, woven or non-woven sheets or films, hydrogel preparations, tissue engineering scaffolds, implants, or metal or polymer materials. Such materials are described in commonly owned U.S. Pat. Nos. 5,358,935, 5,932,552, 6,274,163, 6,124,265, 6,432,435, 6,316,598, 6,371,984, 6274,155, 6,270,793, 6,461,628, and U.S. patent application Ser. No. 09/815,387, all of which are incorporated herein by reference.

Peptide Containing Compositions

In previous studies, crude compositions containing the disclosed peptides have been used to investigate the mitogenic effects on keratinocytes after 3 days of exposure. Peptide concentrations of 0.5 to 10 ug/ml produced increases in optical densities (OD) at 530 nanometer (nm) of greater than 20% compared to negative controls. One exception was the 5 ug/ml concentration that produced over a 15% greater response. The positive control in these studies, epidermal growth factor (EGF25), produced greater than 20% increase in cell proliferation. In a similar study, after 5 days of exposure the keratinocyte proliferation was 25% or greater for peptide concentrations of 0.5 to 10 ug/ml. The positive control, EGF25, also produced a greater than 25% increase.

A second set of studies was performed that tested the biological effect of the peptide compositions on human dermal fibroblasts after three and five days of exposure. After three days of exposure, the peptide composition produced a greater than 25% increase in cell proliferation at concentrations between 0.5 and 10 ug/ml. The positive control, bovine-derived fibroblast growth factor (bFGF25), produced a greater than 30% increase in cell proliferation. After five days of exposure, peptide compositions at a concentration of 0.5 to 10 ug/ml produced increases in cell proliferation of between 9% and 12%. The positive control produced a greater than 13% increase.

Related in vitro tests confirmed that the mitogenic effect of the peptide compositions on dermal fibroblasts increased with concentration up to nearly 150% of the negative control at 1000 ug/ml concentration. Compositions with greater purity increased the mitogenic effect to over 1000% of the negative control. The positive control in these studies, platelet derived growth factor (PDGF), increased the mitogenic effect to nearly 700% of the negative control.

The present disclosure includes further refined preparations that can be separated into two distinct components, the first, alpha-keratose comprises about 60% of the total peptides and is water soluble and acid insoluble. The gamma keratose is both acid and water soluble. Compositions containing mixtures of the disclosed peptides at various concentrations from the alpha and gamma fractions from hair and wool were added to dermal fibroblast cell cultures for three and five days. The cellular response was measured using optical density techniques (OD490) to quantify the cell proliferation. In all cases the highest concentrations produced a greater cell proliferation response than the lower concentrations after three days of exposure. The 100 ug/ml concentration of the peptides from hair and wool produced approximately a 35% and 30% increase in cell proliferation respectively compared to the negative control.

Human dermal fibroblasts were also exposed to alpha and gamma fractions of the peptide compositions products from hair and wool for five days. The negative control was saline, and FGF was used as a positive control. The compositions containing the alpha and gamma fractions of the peptides from hair and wool at 1 and 10 ug/ml concentrations produced an increase in cell proliferation of between 30% and 60% compared to the control.

The peptide compositions reported above were fractionated and amino acid sequences obtained using tandem mass spectrometry (MS/MS). Based on the amino acid sequence data and comparison to known hair and wool keratin proteins, the peptides were localized to a conserved region of human hair and sheep wool keratin proteins. By these sequence comparisons the bioactive peptides are shown to be derived from the following conserved consensus sequence:

EVNTLR(C/S)(Q/P)LGDRLNVEVD(A/T)APTVDLN(Q/R)VLNETR (S/N)QYEAL

The peptide compositions of the present disclosure may contain, therefore, any of the following peptides in any combination.

SEQ ID NO: 1 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 5 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 6 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 7 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 8 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 9 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 10 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 11 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 12 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 13 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 14 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 15 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 16 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 17 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 18 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 19 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 20 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 21 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 22 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 23 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 24 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 25 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 26 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 27 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 28 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 29 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 30 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 31 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 32 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 33 EVNT, SEQ ID NO: 34 VNTL, SEQ ID NO: 35 NTLR, SEQ ID NO: 36 TLRC, SEQ ID NO: 37 TLRS, SEQ ID NO: 38 LRCQ, SEQ ID NO: 39 LRCP, SEQ ID NO: 40 LRSQ, SEQ ID NO: 41 LRSP, SEQ ID NO: 42 RCQL, SEQ ID NO: 43 RSQL, SEQ ID NO: 44 RCPL, SEQ ID NO: 45 RSPL, SEQ ID NO: 46 CQLG, SEQ ID NO: 47 CPLG, SEQ ID NO: 48 SQLG, SEQ ID NO: 49 SPLG, SEQ ID NO: 50 QLGD, SEQ ID NO: 51 PLGD, SEQ ID NO: 52 LGDR, SEQ ID NO: 53 GDRL, SEQ ID NO: 54 DRLN, SEQ ID NO: 55 RLNV, SEQ ID NO: 56 LNVE, SEQ ID NO: 57 NVEV, SEQ ID NO: 58 VEVD, SEQ ID NO: 59 EVDA, SEQ ID NO: 60 EVDT, SEQ ID NO: 61 VDAA, SEQ ID NO: 62 VDTA, SEQ ID NO: 63 DAAP, SEQ ID NO: 64 DTAP, SEQ ID NO: 65 AAPT, SEQ ID NO: 66 TATP, SEQ ID NO: 67 APTV, SEQ ID NO: 68 PTVD, SEQ ID NO: 69 TVDL, SEQ ID NO: 70 VDLN, SEQ ID NO: 71 DLNQ, SEQ ID NO: 72 DLNR, SEQ ID NO: 73 LNQV, SEQ ID NO: 74 LNRV, SEQ ID NO: 75 NQVL, SEQ ID NO: 76 NRVL, SEQ ID NO: 77 QVLN, SEQ ID NO: 78 RVLN, SEQ ID NO: 79 VLNE, SEQ ID NO: 80 LNET, SEQ ID NO: 81 NETR, SEQ ID NO: 82 ETRS, SEQ ID NO: 83 ETRN, SEQ ID NO: 84 TRSQ, SEQ ID NO: 85 TRNQ, SEQ ID NO: 86 RSQY, SEQ ID NO: 87 RNQY, SEQ ID NO: 88 SQYE, SEQ ID NO: 89 NQYE, SEQ ID NO: 90 QYEA, SEQ ID NO: 91 YEAL, SEQ ID NO: 92 EVNTL, SEQ ID NO: 93 VNTLR, SEQ ID NO: 94 NTLRC, SEQ ID NO: 95 NTLRS, SEQ ID NO: 96 TLRCQ, SEQ ID NO: 97 TLRSQ, SEQ ID NO: 98 TLRCP, SEQ ID NO: 99 TLRSP, SEQ ID NO: 100 LRCPL, SEQ ID NO: 101 LRCPL, SEQ ID NO: 102 LRSQL, SEQ ID NO: 103 LRSPL, SEQ ID NO: 104 RCQLG, SEQ ID NO: 105 RCPLG, SEQ ID NO: 106 RSQLG, SEQ ID NO: 107 RSPLG, SEQ ID NO: 108 CQLGD, SEQ ID NO: 109 CPLGD, SEQ ID NO: 110 SQLGD, SEQ ID NO: 111 SPLGD, SEQ ID NO: 112 QLGDR, SEQ ID NO: 113 PLGDR, SEQ ID NO: 114 LGDRL, SEQ ID NO: 115 GDRLN, SEQ ID NO: 116 DRLNV, SEQ ID NO: 117 RLNVE, SEQ ID NO: 118 LNVEV, SEQ ID NO: 119 NVEVD, SEQ ID NO: 120 VEVDA, SEQ ID NO: 121 VEVDT, SEQ ID NO: 122 EVDAA, SEQ ID NO: 123 EVDTA, SEQ ID NO: 124 VDAAP, SEQ ID NO: 125 VDTAP, SEQ ID NO: 126 DAAPT, SEQ ID NO: 127 DTAPT, SEQ ID NO: 128 AAPTV, SEQ ID NO: 129 TAPTV, SEQ ID NO: 130 APTVD, SEQ ID NO: 131 PTVDL, SEQ ID NO: 132 TVDLN, SEQ ID NO: 133 VDLNQ, SEQ ID NO: 134 VDLNR, SEQ ID NO: 135 DLNQV, SEQ ID NO: 136 DLNRV, SEQ ID NO: 137 LNQVL, SEQ ID NO: 138 LNRVL, SEQ ID NO: 139 NQVLN, SEQ ID NO: 140 NRVLN, SEQ ID NO: 141 QVLNE, SEQ ID NO: 142 RVLNE, SEQ ID NO: 143 VLNET, SEQ ID NO: 144 LNETR, SEQ ID NO: 145 NETRS, SEQ ID NO: 146 NETRN, SEQ ID NO: 147 ETRSQ, SEQ ID NO: 148 ETRNQ, SEQ ID NO: 149 TRSQY, SEQ ID NO: 150 TRNQY, SEQ ID NO: 151 RSQYE, SEQ ID NO: 152 RNQYE, SEQ ID NO: 153 SQYEA, SEQ ID NO: 154 NQYEA, SEQ ID NO: 155 QYEAL, SEQ ID NO: 156 EVNTLR, SEQ ID NO: 157 VNTLRC, SEQ ID NO: 158 VNTLRS, SEQ ID NO: 159 NTLRCQ, SEQ ID NO: 160 NTLRCP, SEQ ID NO: 161 NTLRSQ, SEQ ID NO: 162 NTLRSP, SEQ ID NO: 163 TLRCQL, SEQ ID NO: 164 TLRCPL, SEQ ID NO: 165 TLRSQL, SEQ ID NO: 166 TLRSPL, SEQ ID NO: 167 LRCQLG, SEQ ID NO: 168 LRCPLG, SEQ ID NO: 169 LRSQLG, SEQ ID NO: 170 LRSPLG, SEQ ID NO: 171 RCQLGD, SEQ ID NO: 172 RCPLGD, SEQ ID NO: 173 RSQLGD, SEQ ID NO: 174 RSPLGD, SEQ ID NO: 175 CQLGDR, SEQ ID NO: 176 CPLGDR, SEQ ID NO: 177 SQLGDR, SEQ ID NO: 178 SPLGDR, SEQ ID NO: 179 QLGDRL, SEQ ID NO: 180 PLGDRL, SEQ ID NO: 181 LGDRLN, SEQ ID NO: 182 GDRLNV, SEQ ID NO: 183 DRLNVE, SEQ ID NO: 184 RLNVEV, SEQ ID NO: 185 LNVEVD, SEQ ID NO: 186 NVEVDA, SEQ ID NO: 187 NVEVDT, SEQ ID NO: 188 VEVDAA, SEQ ID NO: 189 VEVDTA, SEQ ID NO: 190 EVDAAP, SEQ ID NO: 191 EVDTAP, SEQ ID NO: 192 VDAAPT, SEQ ID NO: 193 VDTAPT, SEQ ID NO: 194 DAAPTV, SEQ ID NO: 195 DTAPTV, SEQ ID NO: 196 AAPTVD, SEQ ID NO: 197 TAPTVD, SEQ ID NO: 198 APTVDL, SEQ ID NO: 199 PTVDLN, SEQ ID NO: 200 TVDLNQ, SEQ ID NO: 201 TVDLNR, SEQ ID NO: 202 VDLNQV, SEQ ID NO: 203 VDLNRV, SEQ ID NO: 204 DLNQVL, SEQ ID NO: 205 DLNRVL, SEQ ID NO: 206 LNQVLN, SEQ ID NO: 207 LNRVLN, SEQ ID NO: 208 NQVLNE, SEQ ID NO: 209 NRVLNE, SEQ ID NO: 210 QVLNET, SEQ ID NO: 211 RVLNET, SEQ ID NO: 212 VLNETR, SEQ ID NO: 213 LNETRS, SEQ ID NO: 214 LNETRN, SEQ ID NO: 215 NETRSQ, SEQ ID NO: 216 NETRNQ, SEQ ID NO: 217 ETRSQY, SEQ ID NO: 218 ETRNQY, SEQ ID NO: 219 TRSQYE, SEQ ID NO: 220 TRNQYE, SEQ ID NO: 221 RSQYEA, SEQ ID NO: 222 RNQYEA, SEQ ID NO: 223 SQYEAL, SEQ ID NO: 224 NQYEAL, SEQ ID NO: 225 EVNTLRC, SEQ ID NO: 226 EVNTLRS, SEQ ID NO: 227 VNTLRCQ, SEQ ID NO: 228 VNTLRCP, SEQ ID NO: 229 VNTLRSQ, SEQ ID NO: 230 VNTLRSP, SEQ ID NO: 231 NTLRCQL, SEQ ID NO: 232 NTLRCPL, SEQ ID NO: 233 NTLRSQL, SEQ ID NO: 234 NTLRSPL, SEQ ID NO: 235 TLRCQLG, SEQ ID NO: 236 TLRCPLG, SEQ ID NO: 237 TLRSQLG, SEQ ID NO: 238 TLRSPLG, SEQ ID NO: 239 LRCQLGD, SEQ ID NO: 240 LRCPLGD, SEQ ID NO: 241 LRSQLGD, SEQ ID NO: 242 LRSPLGD, SEQ ID NO: 243 RCQLGDR, SEQ ID NO: 244 RCPLGDR, SEQ ID NO: 245 RSQLGDR, SEQ ID NO: 246 RSPLGDR, SEQ ID NO: 247 CQLGDRL, SEQ ID NO: 248 CPLGDRL, SEQ ID NO: 249 SQLGDRL, SEQ ID NO: 250 SPLGDRL, SEQ ID NO: 251 QLGDRLN, SEQ ID NO: 252 PLGDRLN, SEQ ID NO: 253 LGDRLNV, SEQ ID NO: 254 GDRLNVE, SEQ ID NO: 255 DRLNVEV, SEQ ID NO: 256 RLNVEVD, SEQ ID NO: 257 LNVEVDA, SEQ ID NO: 258 LNVEVDT, SEQ ID NO: 259 NVEVDAA, SEQ ID NO: 260 NVEVDTA, SEQ ID NO: 261 VEVDAAP, SEQ ID NO: 262 VEVDTAP, SEQ ID NO: 263 EVDAAPT, SEQ ID NO: 264 EVDTAPT, SEQ ID NO: 265 VDAAPTV, SEQ ID NO: 266 VDTAPTV, SEQ ID NO: 267 DAAPTVD, SEQ ID NO: 268 DTAPTVD, SEQ ID NO: 269 AAPTVDL, SEQ ID NO: 270 TAPTVDL, SEQ ID NO: 271 APTVDLN, SEQ ID NO: 272 PTVDLNQ, SEQ ID NO: 273 PTVDLNR, SEQ ID NO: 274 TVDLNQV, SEQ ID NO: 275 TVDLNRV, SEQ ID NO: 276 VDLNQVL, SEQ ID NO: 277 VDLNRVL, SEQ ID NO: 278 DLNQVLN, SEQ ID NO: 279 DLNRVLN, SEQ ID NO: 280 LNQVLNE, SEQ ID NO: 281 LNRVLNE, SEQ ID NO: 282 NQVLNET, SEQ ID NO: 283 NRVLNET, SEQ ID NO: 284 QVLNETR, SEQ ID NO: 285 RVLNETR, SEQ ID NO: 286 VLNETRS, SEQ ID NO: 287 VLNETRN, SEQ ID NO: 288 LNETRSQ, SEQ ID NO: 289 LNETRNQ, SEQ ID NO: 290 NETRSQY, SEQ ID NO: 291 NETRNQY, SEQ ID NO: 292 ETRSQYE, SEQ ID NO: 293 ETRNQYE, SEQ ID NO: 294 TRSQYEA, SEQ ID NO: 295 TRNQYEA, SEQ ID NO: 296 RSQYEAL, SEQ ID NO: 297 RNQYEAL, SEQ ID NO: 298 EVNTLRCQ, SEQ ID NO: 299 EVNTLRCP, SEQ ID NO: 300 EVNTLRSQ, SEQ ID NO: 301 EVNTLRSP, SEQ ID NO: 302 VNTLRCQL, SEQ ID NO: 303 VNTLRCPL, SEQ ID NO: 304 VNTLRSQL, SEQ ID NO: 305 VNTLRSPL, SEQ ID NO: 306 NTLRCQLG, SEQ ID NO: 307 NTLRCPLG, SEQ ID NO: 308 NTLRSQLG, SEQ ID NO: 309 NTLRSPLG, SEQ ID NO: 310 TLRCQLGD, SEQ ID NO: 311 TLRCPLGD, SEQ ID NO: 312 TLRSQLGD, SEQ ID NO: 313 TLRSPLGD, SEQ ID NO: 314 LRCQLGDR, SEQ ID NO: 315 LRCPLGDR, SEQ ID NO: 316 LRSQLGDR, SEQ ID NO: 317 LRSPLGDR, SEQ ID NO: 318 RCQLGDRL, SEQ ID NO: 319 RCPLGDRL, SEQ ID NO: 320 RSQLGDRL, SEQ ID NO: 321 RSPLGDRL, SEQ ID NO: 322 CQLGDRLN, SEQ ID NO: 323 CPLGDRLN, SEQ ID NO: 324 SQLGDRLN, SEQ ID NO: 325 SPLGDRLN, SEQ ID NO: 326 QLGDRLNV, SEQ ID NO: 327 PLGDRLNV, SEQ ID NO: 328 LGDRLNVE, SEQ ID NO: 329 GDRLNVEV, SEQ ID NO: 330 DRLNVEVD, SEQ ID NO: 331 RLNVEVDA, SEQ ID NO: 332 RLNVEVDT, SEQ ID NO: 333 LNVEVDAA, SEQ ID NO: 334 LNVEVDTA, SEQ ID NO: 335 NVEVDAAP, SEQ ID NO: 336 NVEVDTAP, SEQ ID NO: 337 VEVDAAPT, SEQ ID NO: 338 VEVDTAPT, SEQ ID NO: 339 EVDAAPTV, SEQ ID NO: 340 EVDTAPTV, SEQ ID NO: 341 VDAAPTVD, SEQ ID NO: 342 VDTAPTVD, SEQ ID NO: 343 DAAPTVDL, SEQ ID NO: 344 DTAPTVDL, SEQ ID NO: 345 AAPTVDLN, SEQ ID NO: 346 TAPTVDLN, SEQ ID NO: 347 APTVDLNQ, SEQ ID NO: 348 APTVDLNR, SEQ ID NO: 349 PTVDLNQV, SEQ ID NO: 350 PTVDLNRV, SEQ ID NO: 351 TVDLNQVL, SEQ ID NO: 352 TVDLNRVL, SEQ ID NO: 353 VDLNQVLN, SEQ ID NO: 354 VDLNRVLN, SEQ ID NO: 355 DLNQVLNE, SEQ ID NO: 356 DLNRVLNE, SEQ ID NO: 357 LNQVLNET, SEQ ID NO: 358 LNRVLNET, SEQ ID NO: 359 NQVLNETR, SEQ ID NO: 360 NRVLNETR, SEQ ID NO: 361 QVLNETRS, SEQ ID NO: 362 QVLNETRN, SEQ ID NO: 363 RVLNETRS, SEQ ID NO: 364 RVLNETRN, SEQ ID NO: 365 VLNETRSQ, SEQ ID NO: 366 VLNETRNQ, SEQ ID NO: 367 LNETRSQY, SEQ ID NO: 368 LNETRNQY, SEQ ID NO: 369 NETRSQYE, SEQ ID NO: 370 NETRNQYE, SEQ ID NO: 371 ETRSQYEA, SEQ ID NO: 372 ETRNQYEA, SEQ ID NO: 373 TRSQYEAL, SEQ ID NO: 374 TRNQYEAL, SEQ ID NO: 375 EVNTLRCQL, SEQ ID NO: 376 EVNTLRCPL, SEQ ID NO: 377 EVNTLRSQL, SEQ ID NO: 378 EVNTLRSPL, SEQ ID NO: 379 VNTLRCQLG, SEQ ID NO: 380 VNTLRCPLG, SEQ ID NO: 381 VNTLRSQLG, SEQ ID NO: 382 VNTLRSPLG, SEQ ID NO: 383 NTLRCQLGD, SEQ ID NO: 384 NTLRCPLGD, SEQ ID NO: 385 NTLRSQLGD, SEQ ID NO: 386 NTLRSPLGD, SEQ ID NO: 387 TLRCQLGDR, SEQ ID NO: 388 TLRCPLGDR, SEQ ID NO: 389 TLRSQLGDR, SEQ ID NO: 390 TLRSPLGDR, SEQ ID NO: 391 LRCQLGDRL, SEQ ID NO: 392 LRCPLGDRL, SEQ ID NO: 393 LRSQLGDRL, SEQ ID NO: 394 LRSPLGDRL, SEQ ID NO: 395 RCQLGDRLN, SEQ ID NO: 396 RCPLGDRLN, SEQ ID NO: 397 RSQLGDRLN, SEQ ID NO: 398 RSPLGDRLN, SEQ ID NO: 399 CQLGDRLNV, SEQ ID NO: 400 CPLGDRLNV, SEQ ID NO: 401 SQLGDRLNV, SEQ ID NO: 402 SPLGDRLNV, SEQ ID NO: 403 QLGDRLNVE, SEQ ID NO: 404 PLGDRLNVE, SEQ ID NO: 405 LGDRLNVEV, SEQ ID NO: 406 GDRLNVEVD, SEQ ID NO: 407 DRLNVEVDA, SEQ ID NO: 408 DRLNVEVDT, SEQ ID NO: 409 RLNVEVDAA, SEQ ID NO: 410 RLNVEVDTA, SEQ ID NO: 411 LNVEVDAAP, SEQ ID NO: 412 LNVEVDTAP, SEQ ID NO: 413 NVEVDTAPT, SEQ ID NO: 414 NVEVDAAPT, SEQ ID NO: 415 VEVDAAPTV, SEQ ID NO: 416 VEVDTAPTV, SEQ ID NO: 417 EVDAAPTVD, SEQ ID NO: 418 EVDTAPTVD, SEQ ID NO: 419 VDAAPTVDL, SEQ ID NO: 420 VDTAPTVDL, SEQ ID NO: 421 DAAPTVDLN, SEQ ID NO: 422 DTAPTVDLN, SEQ ID NO: 423 AAPTVDLNQ, SEQ ID NO: 424 AAPTVDLNR, SEQ ID NO: 425 TAPTVDLNQ, SEQ ID NO: 426 TAPTVDLNR, SEQ ID NO: 427 APTVDLNQV, SEQ ID NO: 428 APTVDLNRV, SEQ ID NO: 429 PTVDLNQVL, SEQ ID NO: 430 PTVDLNRVL, SEQ ID NO: 431 TVDLNQVLN, SEQ ID NO: 432 TVDLNRVLN, SEQ ID NO: 433 VDLNQVLNE, SEQ ID NO: 434 VDLNRVLNE, SEQ ID NO: 435 DLNQVLNET, SEQ ID NO: 436 DLNRVLNET, SEQ ID NO: 437 LNQVLNETR, SEQ ID NO: 438 LNRVLNETR, SEQ ID NO: 439 NQVLNETRS, SEQ ID NO: 440 NQVLNETRN, SEQ ID NO: 441 NRVLNETRS, SEQ ID NO: 442 NRVLNETRN, SEQ ID NO: 443 QVLNETRSQ, SEQ ID NO: 444 QVLNETRNQ, SEQ ID NO: 445 RVLNETRSQ, SEQ ID NO: 446 RVLNETRNQ, SEQ ID NO: 447 VLNETRSQY, SEQ ID NO: 448 VLNETRNQY, SEQ ID NO: 449 LNETRSQYE, SEQ ID NO: 450 LNETRNQYE, SEQ ID NO: 451 NETRSQYEA, SEQ ID NO: 452 NETRNQYEA, SEQ ID NO: 453 ETRSQYEAL, SEQ ID NO: 454 ETRNQYEAL, SEQ ID NO: 455 EVNTLRCQLG, SEQ ID NO: 456 EVNTLRCPLG, SEQ ID NO: 457 EVNTLRSQLG, SEQ ID NO: 458 EVNTLRSPLG, SEQ ID NO: 459 VNTLRCQLGD, SEQ ID NO: 460 VNTLRCPLGD, SEQ ID NO: 461 VNTLRSQLGD, SEQ ID NO: 462 VNTLRSPLGD, SEQ ID NO: 463 NTLRCQLGDR, SEQ ID NO: 464 NTLRCPLGDR, SEQ ID NO: 465 NTLRSQLGDR, SEQ ID NO: 466 NTLRSPLGDR, SEQ ID NO: 467 TLRCQLGDRL, SEQ ID NO: 468 TLRCPLGDRL, SEQ ID NO: 469 TLRSQLGDRL, SEQ ID NO: 470 TLRSPLGDRL, SEQ ID NO: 471 LRCQLGDRLN, SEQ ID NO: 472 LRCPLGDRLN, SEQ ID NO: 473 LRSQLGDRLN, SEQ ID NO: 474 LRSPLGDRLN, SEQ ID NO: 475 RCQLGDRLNV, SEQ ID NO: 476 RCPLGDRLNV, SEQ ID NO: 477 RSQLGDRLNV, SEQ ID NO: 478 RSPLGDRLNV, SEQ ID NO: 479 CQLGDRLNVE, SEQ ID NO: 480 CPLGDRLNVE, SEQ ID NO: 481 SQLGDRLNVE, SEQ ID NO: 482 SPLGDRLNVE, SEQ ID NO: 483 QLGDRLNVEV, SEQ ID NO: 484 PLGDRLNVEV, SEQ ID NO: 485 LGDRLNVEVD, SEQ ID NO: 486 GDRLNVEVDA, SEQ ID NO: 487 GDRLNVEVDT, SEQ ID NO: 488 DRLNVEVDAA, SEQ ID NO: 489 DRLNVEVDTA, SEQ ID NO: 490 RLNVEVDAAP, SEQ ID NO: 491 RLNVEVDTAP, SEQ ID NO: 492 LNVEVDAAPT, SEQ ID NO: 493 LNVEVDTAPT, SEQ ID NO: 494 NVEVDAAPTV, SEQ ID NO: 495 NVEVDTAPTV, SEQ ID NO: 496 VEVDAAPTVD, SEQ ID NO: 497 VEVDTAPTVD, SEQ ID NO: 498 EVDAAPTVDL, SEQ ID NO: 499 EVDTAPTVDL, SEQ ID NO: 500 VDAAPTVDLN, SEQ ID NO: 501 VDTAPTVDLN, SEQ ID NO: 502 DAAPTVDLNR, SEQ ID NO: 503 DAAPTVDLNQ, SEQ ID NO: 504 DTAPTVDLNR, SEQ ID NO: 505 DTAPTVDLNQ, SEQ ID NO: 506 AAPTVDLNQV, SEQ ID NO: 507 AAPTVDLNRV, SEQ ID NO: 508 TAPTVDLNQV, SEQ ID NO: 509 TAPTVDLNRV, SEQ ID NO: 510 APTVDLNQVL, SEQ ID NO: 511 APTVDLNRVL, SEQ ID NO: 512 PTVDLNQVLN, SEQ ID NO: 513 PTVDLNRVLN, SEQ ID NO: 514 TVDLNQVLNE, SEQ ID NO: 515 TVDLNRVLNE, SEQ ID NO: 516 VDLNQVLNET, SEQ ID NO: 517 VDLNRVLNET, SEQ ID NO: 518 DLNQVLNETR, SEQ ID NO: 519 DLNRVLNETR, SEQ ID NO: 520 LNQVLNETRS, SEQ ID NO: 521 LNQVLNETRN, SEQ ID NO: 522 LNRVLNETRS, SEQ ID NO: 523 LNRVLNETRN, SEQ ID NO: 524 NQVLNETRSQ, SEQ ID NO: 525 NQVLNETRNQ, SEQ ID NO: 526 NRVLNETRSQ, SEQ ID NO: 527 NRVLNETRNQ, SEQ ID NO: 528 QVLNETRSQY, SEQ ID NO: 529 QVLNETRNQY, SEQ ID NO: 530 RVLNETRSQY, SEQ ID NO: 531 RVLNETRNQY, SEQ ID NO: 532 QVLNETRSQY, SEQ ID NO: 533 QVLNETRNQY, SEQ ID NO: 534 RVLNETRSQY, SEQ ID NO: 535 RVLNETRNQY, SEQ ID NO: 536 VLNETRSQYE, SEQ ID NO: 537 VLNETRNQYE, SEQ ID NO: 538 LNETRSQYEA, SEQ ID NO: 539 LNETRNQYEA, SEQ ID NO: 540 NETRSQYEAL, SEQ ID NO: 541 NETRNQYEAL, SEQ ID NO: 542 EVNTLRCQLGD, SEQ ID NO: 543 EVNTLRCPLGD, SEQ ID NO: 544 EVNTLRSQLGD, SEQ ID NO: 545 EVNTLRSPLGD, SEQ ID NO: 546 VNTLRCQLGDR, SEQ ID NO: 547 VNTLRCPLGDR, SEQ ID NO: 548 VNTLRSQLGDR, SEQ ID NO: 549 VNTLRSPLGDR, SEQ ID NO: 550 NTLRCQLGDRL, SEQ ID NO: 551 NTLRCPLGDRL, SEQ ID NO: 552 NTLRSQLGDRL, SEQ ID NO: 553 NTLRSPLGDRL, SEQ ID NO: 554 TLRCQLGDRLN, SEQ ID NO: 555 TLRCPLGDRLN, SEQ ID NO: 556 TLRSQLGDRLN, SEQ ID NO: 557 TLRSPLGDRLN, SEQ ID NO: 558 LRCQLGDRLNV, SEQ ID NO: 559 LRCPLGDRLNV, SEQ ID NO: 560 LRSQLGDRLNV, SEQ ID NO: 561 LRSPLGDRLNV, SEQ ID NO: 562 RCQLGDRLNVE, SEQ ID NO: 563 RCPLGDRLNVE, SEQ ID NO: 564 RSQLGDRLNVE, SEQ ID NO: 565 RSPLGDRLNVE, SEQ ID NO: 566 CQLGDRLNVEV, SEQ ID NO: 567 CPLGDRLNVEV, SEQ ID NO: 568 SQLGDRLNVEV, SEQ ID NO: 569 SPLGDRLNVEV, SEQ ID NO: 570 QLGDRLNVEVD, SEQ ID NO: 571 PLGDRLNVEVD, SEQ ID NO: 572 LGDRLNVEVDA, SEQ ID NO: 573 LGDRLNVEVDT, SEQ ID NO: 574 GDRLNVEVDAA, SEQ ID NO: 575 GDRLNVEVDTA, SEQ ID NO: 576 DRLNVEVDAAP, SEQ ID NO: 577 DRLNVEVDTAP, SEQ ID NO: 578 RLNVEVDAAPT, SEQ ID NO: 579 RLNVEVDTAPT, SEQ ID NO: 580 LNVEVDAAPTV, SEQ ID NO: 581 LNVEVDTAPTV, SEQ ID NO: 582 NVEVDAAPTVD, SEQ ID NO: 583 NVEVDTAPTVD, SEQ ID NO: 584 VEVDAAPTVDL, SEQ ID NO: 585 VEVDTAPTVDL, SEQ ID NO: 586 EVDAAPTVDLN, SEQ ID NO: 587 EVDTAPTVDLN, SEQ ID NO: 588 VDAAPTVDLNQ, SEQ ID NO: 589 VDAAPTVDLNR, SEQ ID NO: 590 VDTAPTVDLNQ, SEQ ID NO: 591 VDTAPTVDLNR, SEQ ID NO: 592 DAAPTVDLNQV, SEQ ID NO: 593 DAAPTVDLNRV, SEQ ID NO: 594 DTAPTVDLNQV, SEQ ID NO: 595 DTAPTVDLNRV, SEQ ID NO: 596 AAPTVDLNQVL, SEQ ID NO: 597 AAPTVDLNRVL, SEQ ID NO: 598 TAPTVDLNQVL, SEQ ID NO: 599 TAPTVDLNRVL, SEQ ID NO: 600 APTVDLNQVLN, SEQ ID NO: 601 APTVDLNRVLN, SEQ ID NO: 602 PTVDLNQVLNE, SEQ ID NO: 603 PTVDLNRVLNE, SEQ ID NO: 604 TVDLNQVLNET, SEQ ID NO: 605 TVDLNRVLNET, SEQ ID NO: 606 VDLNQVLNETR, SEQ ID NO: 607 VDLNRVLNETR, SEQ ID NO: 608 DLNQVLNETRS, SEQ ID NO: 609 DLNQVLNETRN, SEQ ID NO: 610 DLNRVLNETRS, SEQ ID NO: 611 DLNRVLNETRN, SEQ ID NO: 612 LNQVLNETRSQ, SEQ ID NO: 613 LNQVLNETRNQ, SEQ ID NO: 614 LNRVLNETRSQ, SEQ ID NO: 615 LNRVLNETRNQ, SEQ ID NO: 616 NQVLNETRSQY, SEQ ID NO: 617 NQVLNETRNQY, SEQ ID NO: 618 NRVLNETRSQY, SEQ ID NO: 619 NRVLNETRNQY, SEQ ID NO: 620 QVLNETRSQYE, SEQ ID NO: 621 QVLNETRNQYE, SEQ ID NO: 622 RVLNETRSQYE, SEQ ID NO: 623 RVLNETRNQYE, SEQ ID NO: 624 VLNETRSQYEA, SEQ ID NO: 625 VLNETRNQYEA, SEQ ID NO: 626 LNETRSQYEAL, SEQ ID NO: 627 LNETRNQYEAL, SEQ ID NO: 628 EVNTLRCQLGDR, SEQ ID NO: 629 EVNTLRCPLGDR, SEQ ID NO: 630 EVNTLRSQLGDR, SEQ ID NO: 631 EVNTLRSPLGDR, SEQ ID NO: 632 VNTLRCQLGDRL, SEQ ID NO: 633 VNTLRCPLGDRL, SEQ ID NO: 634 VNTLRSQLGDRL, SEQ ID NO: 635 VNTLRSPLGDRL, SEQ ID NO: 636 NTLRCQLGDRLN, SEQ ID NO: 637 NTLRCPLGDRLN, SEQ ID NO: 638 NTLRSQLGDRLN, SEQ ID NO: 639 NTLRSPLGDRLN, SEQ ID NO: 640 TLRCQLGDRLNV, SEQ ID NO: 641 TLRCPLGDRLNV, SEQ ID NO: 642 TLRSQLGDRLNV, SEQ ID NO: 643 TLRSPLGDRLNV, SEQ ID NO: 644 LRCQLGDRLNVE, SEQ ID NO: 645 LRCPLGDRLNVE, SEQ ID NO: 646 LRSQLGDRLNVE, SEQ ID NO: 647 LRSPLGDRLNVE, SEQ ID NO: 648 RCQLGDRLNVEV, SEQ ID NO: 649 RCPLGDRLNVEV, SEQ ID NO: 650 RSQLGDRLNVEV, SEQ ID NO: 651 RSPLGDRLNVEV, SEQ ID NO: 652 CQLGDRLNVEVD, SEQ ID NO: 653 CPLGDRLNVEVD, SEQ ID NO: 654 SQLGDRLNVEVD, SEQ ID NO: 655 SPLGDRLNVEVD, SEQ ID NO: 656 QLGDRLNVEVDA, SEQ ID NO: 657 QLGDRLNVEVDT, SEQ ID NO: 658 PLGDRLNVEVDA, SEQ ID NO: 659 PLGDRLNVEVDT, SEQ ID NO: 660 LGDRLNVEVDAA, SEQ ID NO: 661 LGDRLNVEVDTA, SEQ ID NO: 662 GDRLNVEVDAAP, SEQ ID NO: 663 GDRLNVEVDTAP, SEQ ID NO: 664 DRLNVEVDAAPT, SEQ ID NO: 665 DRLNVEVDTAPT, SEQ ID NO: 666 RLNVEVDAAPTV, SEQ ID NO: 667 RLNVEVDTAPTV, SEQ ID NO: 668 LNVEVDAAPTVD, SEQ ID NO: 669 LNVEVDTAPTVD, SEQ ID NO: 670 NVEVDAAPTVDL, SEQ ID NO: 671 NVEVDTAPTVDL, SEQ ID NO: 672 VEVDAAPTVDLN, SEQ ID NO: 673 VEVDTAPTVDLN, SEQ ID NO: 674 EVDAAPTVDLNQ, SEQ ID NO: 675 EVDAAPTVDLNR, SEQ ID NO: 676 EVDTAPTVDLNQ, SEQ ID NO: 677 EVDTAPTVDLNR, SEQ ID NO: 678 VDAAPTVDLNQV, SEQ ID NO: 679 VDAAPTVDLNRV, SEQ ID NO: 680 VDTAPTVDLNQV, SEQ ID NO: 681 VDTAPTVDLNRV, SEQ ID NO: 682 DAAPTVDLNQVL, SEQ ID NO: 683 DAAPTVDLNRVL, SEQ ID NO: 684 DTAPTVDLNQVL, SEQ ID NO: 685 DTAPTVDLNRVL, SEQ ID NO: 686 AAPTVDLNQVLN, SEQ ID NO: 687 AAPTVDLNRVLN, SEQ ID NO: 688 TAPTVDLNQVLN, SEQ ID NO: 689 TAPTVDLNRVLN, SEQ ID NO: 690 APTVDLNQVLNE, SEQ ID NO: 691 APTVDLNRVLNE, SEQ ID NO: 692 PTVDLNQVLNET, SEQ ID NO: 693 PTVDLNRVLNET, SEQ ID NO: 694 TVDLNQVLNETR, SEQ ID NO: 695 TVDLNRVLNETR, SEQ ID NO: 696 VDLNQVLNETRS, SEQ ID NO: 697 VDLNQVLNETRN, SEQ ID NO: 698 VDLNRVLNETRS, SEQ ID NO: 699 VDLNRVLNETRN, SEQ ID NO: 700 DLNQVLNETRSQ, SEQ ID NO: 701 DLNQVLNETRNQ, SEQ ID NO: 702 DLNRVLNETRSQ, SEQ ID NO: 703 DLNRVLNETRNQ, SEQ ID NO: 704 LNQVLNETRSQY, SEQ ID NO: 705 LNQVLNETRNQY, SEQ ID NO: 706 LNRVLNETRSQY, SEQ ID NO: 707 LNRVLNETRNQY, SEQ ID NO: 708 NQVLNETRSQYE, SEQ ID NO: 709 LNQVLNETRNQY, SEQ ID NO: 710 LNRVLNETRSQY, SEQ ID NO: 711 LNRVLNETRNQY, SEQ ID NO: 712 QVLNETRSQYEA, SEQ ID NO: 713 QVLNETRNQYEA, SEQ ID NO: 714 RVLNETRSQYEA, SEQ ID NO: 715 RVLNETRNQYEA, SEQ ID NO: 716 VLNETRSQYEAL, SEQ ID NO: 717 VLNETRNQYEAL, SEQ ID NO: 718 EVNTLRCQLGDRL, SEQ ID NO: 719 EVNTLRCPLGDRL, SEQ ID NO: 720 EVNTLRSQLGDRL, SEQ ID NO: 721 EVNTLRSPLGDRL, SEQ ID NO: 722 VNTLRCQLGDRLN, SEQ ID NO: 723 VNTLRCPLGDRLN, SEQ ID NO: 724 VNTLRSQLGDRLN, SEQ ID NO: 725 VNTLRSPLGDRLN, SEQ ID NO: 726 NTLRCQLGDRLNV, SEQ ID NO: 727 NTLRCPLGDRLNV, SEQ ID NO: 728 NTLRSQLGDRLNV, SEQ ID NO: 729 NTLRSPLGDRLNV, SEQ ID NO: 730 TLRCQLGDRLNVE, SEQ ID NO: 731 TLRCPLGDRLNVE, SEQ ID NO: 732 TLRSQLGDRLNVE, SEQ ID NO: 733 TLRSPLGDRLNVE, SEQ ID NO: 734 LRCQLGDRLNVEV, SEQ ID NO: 735 LRCPLGDRLNVEV, SEQ ID NO: 736 LRSQLGDRLNVEV, SEQ ID NO: 737 LRSPLGDRLNVEV, SEQ ID NO: 738 RCQLGDRLNVEVD, SEQ ID NO: 739 RCPLGDRLNVEVD, SEQ ID NO: 740 RSQLGDRLNVEVD, SEQ ID NO: 741 RSPLGDRLNVEVD, SEQ ID NO: 742 CQLGDRLNVEVDA, SEQ ID NO: 743 CQLGDRLNVEVDT, SEQ ID NO: 744 CPLGDRLNVEVDA, SEQ ID NO: 745 CPLGDRLNVEVDT, SEQ ID NO: 746 SQLGDRLNVEVDA, SEQ ID NO: 747 SQLGDRLNVEVDT, SEQ ID NO: 748 SPLGDRLNVEVDA, SEQ ID NO: 749 SPLGDRLNVEVDT, SEQ ID NO: 750 QLGDRLNVEVDAA, SEQ ID NO: 751 QLGDRLNVEVDTA, SEQ ID NO: 752 PLGDRLNVEVDAA, SEQ ID NO: 753 PLGDRLNVEVDTA, SEQ ID NO: 754 LGDRLNVEVDAAP, SEQ ID NO: 755 LGDRLNVEVDTAP, SEQ ID NO: 756 GDRLNVEVDAAPT, SEQ ID NO: 757 GDRLNVEVDTAPT, SEQ ID NO: 758 DRLNVEVDAAPTV, SEQ ID NO: 759 DRLNVEVDTAPTV, SEQ ID NO: 760 RLNVEVDAAPTVD, SEQ ID NO: 761 RLNVEVDTAPTVD, SEQ ID NO: 762 LNVEVDAAPTVDL, SEQ ID NO: 763 LNVEVDTAPTVDL, SEQ ID NO: 764 NVEVDAAPTVDLN, SEQ ID NO: 765 NVEVDTAPTVDLN, SEQ ID NO: 766 VEVDAAPTVDLNQ, SEQ ID NO: 767 VEVDAAPTVDLNR, SEQ ID NO: 768 VEVDTAPTVDLNQ, SEQ ID NO: 769 VEVDTAPTVDLNR, SEQ ID NO: 770 EVDAAPTVDLNQV, SEQ ID NO: 771 EVDAAPTVDLNRV, SEQ ID NO: 772 EVDTAPTVDLNQV, SEQ ID NO: 773 EVDTAPTVDLNRV, SEQ ID NO: 774 VDAAPTVDLNQVL, SEQ ID NO: 775 VDAAPTVDLNRVL, SEQ ID NO: 776 VDTAPTVDLNQVL, SEQ ID NO: 777 VDTAPTVDLNRVL, SEQ ID NO: 778 DAAPTVDLNQVLN, SEQ ID NO: 779 DAAPTVDLNRVLN, SEQ ID NO: 780 DTAPTVDLNQVLN, SEQ ID NO: 781 DTAPTVDLNRVLN, SEQ ID NO: 782 AAPTVDLNQVLNE, SEQ ID NO: 783 AAPTVDLNRVLNE, SEQ ID NO: 784 TAPTVDLNQVLNE, SEQ ID NO: 785 TAPTVDLNRVLNE, SEQ ID NO: 786 APTVDLNQVLNET, SEQ ID NO: 787 APTVDLNRVLNET, SEQ ID NO: 788 PTVDLNQVLNETR, SEQ ID NO: 789 PTVDLNRVLNETR, SEQ ID NO: 790 TVDLNQVLNETRS, SEQ ID NO: 791 TVDLNQVLNETRN, SEQ ID NO: 792 TVDLNRVLNETRS, SEQ ID NO: 793 TVDLNRVLNETRN, SEQ ID NO: 794 VDLNQVLNETRSQ, SEQ ID NO: 795 VDLNQVLNETRNQ, SEQ ID NO: 796 VDLNRVLNETRSQ, SEQ ID NO: 797 VDLNRVLNETRNQ, SEQ ID NO: 798 DLNQVLNETRSQY, SEQ ID NO: 799 DLNQVLNETRNQY, SEQ ID NO: 800 DLNRVLNETRSQY, SEQ ID NO: 801 DLNRVLNETRNQY, SEQ ID NO: 802 LNQVLNETRSQYE, SEQ ID NO: 803 LNQVLNETRNQYE, SEQ ID NO: 804 LNRVLNETRSQYE, SEQ ID NO: 805 LNRVLNETRNQYE, SEQ ID NO: 806 NQVLNETRSQYEA, SEQ ID NO: 807 NQVLNETRNQYEA, SEQ ID NO: 808 NRVLNETRSQYEA, SEQ ID NO: 809 NRVLNETRNQYEA, SEQ ID NO: 810 QVLNETRSQYEAL, SEQ ID NO: 811 QVLNETRNQYEAL, SEQ ID NO: 812 RVLNETRSQYEAL, SEQ ID NO: 813 RVLNETRNQYEAL, SEQ ID NO: 814 EVNTLRCQLGDRLN, SEQ ID NO: 815 EVNTLRCPLGDRLN, SEQ ID NO: 816 EVNTLRSQLGDRLN, SEQ ID NO: 817 EVNTLRSPLGDRLN, SEQ ID NO: 818 VNTLRCQLGDRLNV, SEQ ID NO: 819 VNTLRCPLGDRLNV, SEQ ID NO: 820 VNTLRSQLGDRLNV, SEQ ID NO: 821 VNTLRSPLGDRLNV, SEQ ID NO: 822 NTLRCQLGDRLNVE, SEQ ID NO: 823 NTLRCPLGDRLNVE, SEQ ID NO: 824 NTLRSQLGDRLNVE, SEQ ID NO: 825 NTLRSPLGDRLNVE, SEQ ID NO: 826 TLRCQLGDRLNVEV, SEQ ID NO: 827 TLRCPLGDRLNVEV, SEQ ID NO: 828 TLRSQLGDRLNVEV, SEQ ID NO: 829 TLRSPLGDRLNVEV, SEQ ID NO: 830 LRCQLGDRLNVEVD, SEQ ID NO: 831 LRCPLGDRLNVEVD, SEQ ID NO: 832 LRSQLGDRLNVEVD, SEQ ID NO: 833 LRSPLGDRLNVEVD, SEQ ID NO: 834 RCQLGDRLNVEVDA, SEQ ID NO: 835 RCQLGDRLNVEVDT, SEQ ID NO: 836 RCPLGDRLNVEVDA, SEQ ID NO: 837 RCPLGDRLNVEVDT, SEQ ID NO: 838 RSQLGDRLNVEVDA, SEQ ID NO: 839 RSQLGDRLNVEVDT, SEQ ID NO: 840 RSPLGDRLNVEVDA, SEQ ID NO: 841 RSPLGDRLNVEVDT, SEQ ID NO: 842 CQLGDRLNVEVDAA, SEQ ID NO: 843 CQLGDRLNVEVDTA, SEQ ID NO: 844 CPLGDRLNVEVDAA, SEQ ID NO: 845 CPLGDRLNVEVDTA, SEQ ID NO: 846 SQLGDRLNVEVDAA, SEQ ID NO: 847 SQLGDRLNVEVDTA, SEQ ID NO: 848 SPLGDRLNVEVDAA, SEQ ID NO: 849 SPLGDRLNVEVDTA, SEQ ID NO: 850 QLGDRLNVEVDAAP, SEQ ID NO: 851 QLGDRLNVEVDTAP, SEQ ID NO: 852 PLGDRLNVEVDAAP, SEQ ID NO: 853 PLGDRLNVEVDTAP, SEQ ID NO: 854 LGDRLNVEVDAAPT, SEQ ID NO: 855 LGDRLNVEVDTAPT, SEQ ID NO: 856 GDRLNVEVDAAPTV, SEQ ID NO: 857 GDRLNVEVDTAPTV, SEQ ID NO: 858 DRLNVEVDAAPTVD, SEQ ID NO: 859 DRLNVEVDTAPTVD, SEQ ID NO: 860 RLNVEVDAAPTVDL, SEQ ID NO: 861 RLNVEVDTAPTVDL, SEQ ID NO: 862 LNVEVDAAPTVDLN, SEQ ID NO: 863 LNVEVDTAPTVDLN, SEQ ID NO: 864 NVEVDAAPTVDLNQ, SEQ ID NO: 865 NVEVDAAPTVDLNR, SEQ ID NO: 866 NVEVDTAPTVDLNQ, SEQ ID NO: 867 NVEVDTAPTVDLNR, SEQ ID NO: 868 VEVDAAPTVDLNQV, SEQ ID NO: 869 VEVDAAPTVDLNRV, SEQ ID NO: 870 VEVDTAPTVDLNQV, SEQ ID NO: 871 VEVDTAPTVDLNRV, SEQ ID NO: 872 EVDAAPTVDLNQVL, SEQ ID NO: 873 EVDAAPTVDLNRVL, SEQ ID NO: 874 EVDTAPTVDLNQVL, SEQ ID NO: 875 EVDTAPTVDLNRVL, SEQ ID NO: 876 VDAAPTVDLNQVLN, SEQ ID NO: 877 VDAAPTVDLNRVLN, SEQ ID NO: 878 VDTAPTVDLNQVLN, SEQ ID NO: 879 VDTAPTVDLNRVLN, SEQ ID NO: 880 DAAPTVDLNQVLNE, SEQ ID NO: 881 DAAPTVDLNRVLNE, SEQ ID NO: 882 DTAPTVDLNQVLNE, SEQ ID NO: 883 DTAPTVDLNRVLNE, SEQ ID NO: 884 AAPTVDLNQVLNET, SEQ ID NO: 885 AAPTVDLNRVLNET, SEQ ID NO: 886 TAPTVDLNQVLNET, SEQ ID NO: 887 TAPTVDLNRVLNET, SEQ ID NO: 888 APTVDLNQVLNETR, SEQ ID NO: 889 APTVDLNRVLNETR, SEQ ID NO: 890 PTVDLNQVLNETRS, SEQ ID NO: 891 PTVDLNQVLNETRN, SEQ ID NO: 892 PTVDLNRVLNETRS, SEQ ID NO: 893 PTVDLNRVLNETRN, SEQ ID NO: 894 TVDLNQVLNETRSQ, SEQ ID NO: 895 TVDLNQVLNETRNQ, SEQ ID NO: 896 TVDLNRVLNETRSQ, SEQ ID NO: 897 TVDLNRVLNETRNQ, SEQ ID NO: 898 VDLNQVLNETRSQY, SEQ ID NO: 899 VDLNQVLNETRNQY, SEQ ID NO: 900 VDLNRVLNETRSQY, SEQ ID NO: 901 VDLNRVLNETRNQY, SEQ ID NO: 902 DLNQVLNETRSQYE, SEQ ID NO: 903 DLNQVLNETRNQYE, SEQ ID NO: 904 DLNRVLNETRSQYE, SEQ ID NO: 905 DLNRVLNETRNQYE, SEQ ID NO: 906 LNQVLNETRSQYEA, SEQ ID NO: 907 LNQVLNETRNQYEA, SEQ ID NO: 908 LNRVLNETRSQYEA, SEQ ID NO: 909 LNRVLNETRNQYEA, SEQ ID NO: 910 NQVLNETRSQYEAL, SEQ ID NO: 911 NQVLNETRNQYEAL, SEQ ID NO: 912 NRVLNETRSQYEAL, SEQ ID NO: 913 NRVLNETRNQYEAL, SEQ ID NO: 914 EVNTLRCQLGDRLNV, SEQ ID NO: 915 EVNTLRCPLGDRLNV, SEQ ID NO: 916 EVNTLRSQLGDRLNV, SEQ ID NO: 917 EVNTLRSPLGDRLNV, SEQ ID NO: 918 VNTLRCQLGDRLNVE, SEQ ID NO: 919 VNTLRCPLGDRLNVE, SEQ ID NO: 920 VNTLRSQLGDRLNVE, SEQ ID NO: 921 VNTLRSPLGDRLNVE, SEQ ID NO: 922 NTLRCQLGDRLNVEV, SEQ ID NO: 923 NTLRCPLGDRLNVEV, SEQ ID NO: 924 NTLRSQLGDRLNVEV, SEQ ID NO: 925 NTLRSPLGDRLNVEV, SEQ ID NO: 926 TLRCQLGDRLNVEVD, SEQ ID NO: 927 TLRCPLGDRLNVEVD, SEQ ID NO: 928 TLRSQLGDRLNVEVD, SEQ ID NO: 929 TLRSPLGDRLNVEVD, SEQ ID NO: 930 LRCQLGDRLNVEVDA, SEQ ID NO: 931 LRCQLGDRLNVEVDT, SEQ ID NO: 932 LRCPLGDRLNVEVDA, SEQ ID NO: 933 LRCPLGDRLNVEVDT, SEQ ID NO: 934 LRSQLGDRLNVEVDA, SEQ ID NO: 935 LRSQLGDRLNVEVDT, SEQ ID NO: 936 LRSPLGDRLNVEVDA, SEQ ID NO: 937 LRSPLGDRLNVEVDT, SEQ ID NO: 938 RCQLGDRLNVEVDAA, SEQ ID NO: 939 RCQLGDRLNVEVDTA, SEQ ID NO: 940 RCPLGDRLNVEVDAA, SEQ ID NO: 941 RCPLGDRLNVEVDTA, SEQ ID NO: 942 RSQLGDRLNVEVDAA, SEQ ID NO: 943 RSQLGDRLNVEVDTA, SEQ ID NO: 944 RSPLGDRLNVEVDAA, SEQ ID NO: 945 RSPLGDRLNVEVDTA, SEQ ID NO: 946 CQLGDRLNVEVDAAP, SEQ ID NO: 947 CQLGDRLNVEVDTAP, SEQ ID NO: 948 CPLGDRLNVEVDAAP, SEQ ID NO: 949 CPLGDRLNVEVDTAP, SEQ ID NO: 950 SQLGDRLNVEVDAAP, SEQ ID NO: 951 SQLGDRLNVEVDTAP, SEQ ID NO: 952 SPLGDRLNVEVDAAP, SEQ ID NO: 953 SPLGDRLNVEVDTAP, SEQ ID NO: 954 QLGDRLNVEVDAAPT, SEQ ID NO: 955 QLGDRLNVEVDTAPT, SEQ ID NO: 956 PLGDRLNVEVDAAPT, SEQ ID NO: 957 PLGDRLNVEVDTAPT, SEQ ID NO: 958 LGDRLNVEVDAAPTV, SEQ ID NO: 959 LGDRLNVEVDTAPTV, SEQ ID NO: 960 GDRLNVEVDAAPTVD, SEQ ID NO: 961 GDRLNVEVDTAPTVD, SEQ ID NO: 962 DRLNVEVDAAPTVDL, SEQ ID NO: 963 DRLNVEVDTAPTVDL, SEQ ID NO: 964 RLNVEVDAAPTVDLN, SEQ ID NO: 965 RLNVEVDTAPTVDLN, SEQ ID NO: 966 LNVEVDAAPTVDLNQ, SEQ ID NO: 967 LNVEVDAAPTVDLNR, SEQ ID NO: 968 LNVEVDTAPTVDLNQ, SEQ ID NO: 969 LNVEVDTAPTVDLNR, SEQ ID NO: 970 NVEVDAAPTVDLNQV, SEQ ID NO: 971 NVEVDAAPTVDLNRV, SEQ ID NO: 972 NVEVDTAPTVDLNQV, SEQ ID NO: 973 NVEVDTAPTVDLNRV, SEQ ID NO: 974 VEVDAAPTVDLNQVL, SEQ ID NO: 975 VEVDAAPTVDLNRVL, SEQ ID NO: 976 VEVDTAPTVDLNQVL, SEQ ID NO: 977 VEVDTAPTVDLNRVL, SEQ ID NO: 978 EVDAAPTVDLNQVLN, SEQ ID NO: 979 EVDAAPTVDLNRVLN, SEQ ID NO: 980 EVDTAPTVDLNQVLN, SEQ ID NO: 981 EVDTAPTVDLNRVLN, SEQ ID NO: 982 VDAAPTVDLNQVLNE, SEQ ID NO: 983 VDAAPTVDLNRVLNE, SEQ ID NO: 984 VDTAPTVDLNQVLNE, SEQ ID NO: 985 VDTAPTVDLNRVLNE, SEQ ID NO: 986 DAAPTVDLNQVLNET, SEQ ID NO: 987 DAAPTVDLNRVLNET, SEQ ID NO: 988 DTAPTVDLNQVLNET, SEQ ID NO: 989 DTAPTVDLNRVLNET, SEQ ID NO: 990 AAPTVDLNQVLNETR, SEQ ID NO: 991 AAPTVDLNRVLNETR, SEQ ID NO: 992 TAPTVDLNQVLNETR, SEQ ID NO: 993 TAPTVDLNRVLNETR, SEQ ID NO: 994 APTVDLNQVLNETRS, SEQ ID NO: 995 APTVDLNQVLNETRN, SEQ ID NO: 996 APTVDLNRVLNETRS, SEQ ID NO: 997 APTVDLNRVLNETRN, SEQ ID NO: 998 PTVDLNQVLNETRSQ, SEQ ID NO: 999 PTVDLNQVLNETRNQ, SEQ ID NO: 1000 PTVDLNRVLNETRSQ, SEQ ID NO: 1001 PTVDLNRVLNETRNQ, SEQ ID NO: 1002 TVDLNQVLNETRSQY, SEQ ID NO: 1003 TVDLNQVLNETRNQY, SEQ ID NO: 1004 TVDLNRVLNETRSQY, SEQ ID NO: 1005 TVDLNRVLNETRNQY, SEQ ID NO: 1006 VDLNQVLNETRSQYE, SEQ ID NO: 1007 VDLNQVLNETRNQYE, SEQ ID NO: 1008 VDLNRVLNETRSQYE, SEQ ID NO: 1009 VDLNRVLNETRNQYE, SEQ ID NO: 1010 DLNQVLNETRSQYEA, SEQ ID NO: 1011 DLNQVLNETRNQYEA, SEQ ID NO: 1012 DLNRVLNETRSQYEA, SEQ ID NO: 1013 DLNRVLNETRNQYEA, SEQ ID NO: 1014 LNQVLNETRSQYEAL, SEQ ID NO: 1015 LNQVLNETRNQYEAL, SEQ ID NO: 1016 LNRVLNETRSQYEAL, SEQ ID NO: 1017 LNRVLNETRNQYEAL, SEQ ID NO: 1018 EVNTLRCQLGDRLNVE, SEQ ID NO: 1019 EVNTLRCPLGDRLNVE, SEQ ID NO: 1020 EVNTLRSQLGDRLNVE, SEQ ID NO: 1021 EVNTLRSPLGDRLNVE, SEQ ID NO: 1022 VNTLRCQLGDRLNVEV, SEQ ID NO: 1023 VNTLRCPLGDRLNVEV, SEQ ID NO: 1024 VNTLRSQLGDRLNVEV, SEQ ID NO: 1025 VNTLRSPLGDRLNVEV, SEQ ID NO: 1026 NTLRCQLGDRLNVEVD, SEQ ID NO: 1027 NTLRCPLGDRLNVEVD, SEQ ID NO: 1028 NTLRSQLGDRLNVEVD, SEQ ID NO: 1029 NTLRSPLGDRLNVEVD, SEQ ID NO: 1030 TLRCQLGDRLNVEVDA, SEQ ID NO: 1031 TLRCQLGDRLNVEVDT, SEQ ID NO: 1032 TLRCPLGDRLNVEVDA, SEQ ID NO: 1033 TLRCPLGDRLNVEVDT, SEQ ID NO: 1034 TLRSQLGDRLNVEVDA, SEQ ID NO: 1035 TLRSQLGDRLNVEVDT, SEQ ID NO: 1036 TLRSPLGDRLNVEVDA, SEQ ID NO: 1037 TLRSPLGDRLNVEVDT, SEQ ID NO: 1038 LRCQLGDRLNVEVDAA, SEQ ID NO: 1039 LRCQLGDRLNVEVDTA, SEQ ID NO: 1040 LRCPLGDRLNVEVDAA, SEQ ID NO: 1041 LRCPLGDRLNVEVDTA, SEQ ID NO: 1042 LRSQLGDRLNVEVDAA, SEQ ID NO: 1043 LRSQLGDRLNVEVDTA, SEQ ID NO: 1044 LRSPLGDRLNVEVDAA, SEQ ID NO: 1045 LRSPLGDRLNVEVDTA, SEQ ID NO: 1046 RCQLGDRLNVEVDAAP, SEQ ID NO: 1047 RCQLGDRLNVEVDTAP, SEQ ID NO: 1048 RCPLGDRLNVEVDAAP, SEQ ID NO: 1049 RCPLGDRLNVEVDTAP, SEQ ID NO: 1050 RSQLGDRLNVEVDAAP, SEQ ID NO: 1051 RSQLGDRLNVEVDTAP, SEQ ID NO: 1052 RSPLGDRLNVEVDAAP, SEQ ID NO: 1053 RSPLGDRLNVEVDTAP, SEQ ID NO: 1054 CQLGDRLNVEVDAAPT, SEQ ID NO: 1055 CQLGDRLNVEVDTAPT, SEQ ID NO: 1056 CPLGDRLNVEVDAAPT, SEQ ID NO: 1057 CPLGDRLNVEVDTAPT, SEQ ID NO: 1058 SQLGDRLNVEVDAAPT, SEQ ID NO: 1059 SQLGDRLNVEVDTAPT, SEQ ID NO: 1060 SPLGDRLNVEVDAAPT, SEQ ID NO: 1061 SPLGDRLNVEVDTAPT, SEQ ID NO: 1062 QLGDRLNVEVDAAPTV, SEQ ID NO: 1063 QLGDRLNVEVDTAPTV, SEQ ID NO: 1064 PLGDRLNVEVDAAPTV, SEQ ID NO: 1065 PLGDRLNVEVDTAPTV, SEQ ID NO: 1066 LGDRLNVEVDAAPTVD, SEQ ID NO: 1067 LGDRLNVEVDTAPTVD, SEQ ID NO: 1068 GDRLNVEVDAAPTVDL, SEQ ID NO: 1069 GDRLNVEVDTAPTVDL, SEQ ID NO: 1070 DRLNVEVDAAPTVDLN, SEQ ID NO: 1071 DRLNVEVDTAPTVDLN, SEQ ID NO: 1072 RLNVEVDAAPTVDLNQ, SEQ ID NO: 1073 RLNVEVDAAPTVDLNR, SEQ ID NO: 1074 RLNVEVDTAPTVDLNQ, SEQ ID NO: 1075 RLNVEVDTAPTVDLNR, SEQ ID NO: 1076 LNVEVDAAPTVDLNQV, SEQ ID NO: 1077 LNVEVDAAPTVDLNRV, SEQ ID NO: 1078 LNVEVDTAPTVDLNQV, SEQ ID NO: 1079 LNVEVDTAPTVDLNRV, SEQ ID NO: 1080 NVEVDAAPTVDLNQVL, SEQ ID NO: 1081 NVEVDAAPTVDLNQVL, SEQ ID NO: 1082 NVEVDTAPTVDLNQVL, SEQ ID NO: 1083 NVEVDTAPTVDLNRVL, SEQ ID NO: 1084 VEVDAAPTVDLNQVLN, SEQ ID NO: 1085 VEVDAAPTVDLNRVLN, SEQ ID NO: 1086 VEVDTAPTVDLNQVLN, SEQ ID NO: 1087 VEVDTAPTVDLNRVLN, SEQ ID NO: 1088 EVDAAPTVDLNQVLNE, SEQ ID NO: 1089 EVDAAPTVDLNRVLNE, SEQ ID NO: 1090 EVDTAPTVDLNQVLNE, SEQ ID NO: 1091 EVDTAPTVDLNRVLNE, SEQ ID NO: 1092 VDAAPTVDLNQVLNET, SEQ ID NO: 1093 VDAAPTVDLNRVLNET, SEQ ID NO: 1094 VDTAPTVDLNQVLNET, SEQ ID NO: 1095 VDTAPTVDLNRVLNET, SEQ ID NO: 1096 DAAPTVDLNQVLNETR, SEQ ID NO: 1097 DAAPTVDLNRVLNETR, SEQ ID NO: 1098 DTAPTVDLNQVLNETR, SEQ ID NO: 1099 DTAPTVDLNRVLNETR, SEQ ID NO: 1100 AAPTVDLNQVLNETRS, SEQ ID NO: 1101 AAPTVDLNQVLNETRN, SEQ ID NO: 1102 AAPTVDLNRVLNETRS, SEQ ID NO: 1103 AAPTVDLNRVLNETRN, SEQ ID NO: 1104 TAPTVDLNQVLNETRS, SEQ ID NO: 1105 TAPTVDLNQVLNETRN, SEQ ID NO: 1106 TAPTVDLNRVLNETRS, SEQ ID NO: 1107 TAPTVDLNRVLNETRN, SEQ ID NO: 1108 APTVDLNQVLNETRSQ, SEQ ID NO: 1109 APTVDLNQVLNETRNQ, SEQ ID NO: 1110 APTVDLNRVLNETRSQ, SEQ ID NO: 1111 APTVDLNRVLNETRNQ, SEQ ID NO: 1112 PTVDLNQVLNETRSQY, SEQ ID NO: 1113 PTVDLNQVLNETRNQY, SEQ ID NO: 1114 PTVDLNRVLNETRSQY, SEQ ID NO: 1115 PTVDLNRVLNETRNQY, SEQ ID NO: 1116 TVDLNQVLNETRSQYE, SEQ ID NO: 1117 TVDLNQVLNETRNQYE, SEQ ID NO: 1118 TVDLNRVLNETRSQYE, SEQ ID NO: 1119 TVDLNRVLNETRNQYE, SEQ ID NO: 1120 VDLNQVLNETRSQYEA, SEQ ID NO: 1121 VDLNQVLNETRNQYEA, SEQ ID NO: 1122 VDLNRVLNETRSQYEA, SEQ ID NO: 1123 VDLNRVLNETRNQYEA, SEQ ID NO: 1124 DLNQVLNETRSQYEAL, SEQ ID NO: 1125 DLNQVLNETRNQYEAL, SEQ ID NO: 1126 DLNRVLNETRSQYEAL, SEQ ID NO: 1127 DLNRVLNETRNQYEAL, SEQ ID NO: 1128 EVNTLRCQLGDRLNVEV, SEQ ID NO: 1129 EVNTLRCPLGDRLNVEV, SEQ ID NO: 1130 EVNTLRSQLGDRLNVEV, SEQ ID NO: 1131 EVNTLRSPLGDRLNVEV, SEQ ID NO: 1132 VNTLRCQLGDRLNVEVD, SEQ ID NO: 1133 VNTLRCPLGDRLNVEVD, SEQ ID NO: 1134 VNTLRSQLGDRLNVEVD, SEQ ID NO: 1135 VNTLRSPLGDRLNVEVD, SEQ ID NO: 1136 NTLRCQLGDRLNVEVDA, SEQ ID NO: 1137 NTLRCQLGDRLNVEVDT, SEQ ID NO: 1138 NTLRCPLGDRLNVEVDA, SEQ ID NO: 1139 NTLRCPLGDRLNVEVDT, SEQ ID NO: 1140 NTLRSQLGDRLNVEVDA, SEQ ID NO: 1141 NTLRSQLGDRLNVEVDT, SEQ ID NO: 1142 NTLRSPLGDRLNVEVDA, SEQ ID NO: 1143 NTLRSPLGDRLNVEVDT, SEQ ID NO: 1144 TLRCQLGDRLNVEVDAA, SEQ ID NO: 1145 TLRCQLGDRLNVEVDTA, SEQ ID NO: 1146 TLRCPLGDRLNVEVDAA, SEQ ID NO: 1147 TLRCPLGDRLNVEVDTA, SEQ ID NO: 1148 TLRSQLGDRLNVEVDAA, SEQ ID NO: 1149 TLRSQLGDRLNVEVDTA, SEQ ID NO: 1150 TLRSPLGDRLNVEVDAA, SEQ ID NO: 1151 TLRSPLGDRLNVEVDTA, SEQ ID NO: 1152 LRCQLGDRLNVEVDAAP, SEQ ID NO: 1153 LRCQLGDRLNVEVDTAP, SEQ ID NO: 1154 LRCPLGDRLNVEVDAAP, SEQ ID NO: 1155 LRCPLGDRLNVEVDTAP, SEQ ID NO: 1156 LRSQLGDRLNVEVDAAP, SEQ ID NO: 1157 LRSQLGDRLNVEVDTAP, SEQ ID NO: 1158 LRSPLGDRLNVEVDAAP, SEQ ID NO: 1159 LRSPLGDRLNVEVDTAP, SEQ ID NO: 1160 RCQLGDRLNVEVDAAPT, SEQ ID NO: 1161 RCQLGDRLNVEVDTAPT, SEQ ID NO: 1162 RCPLGDRLNVEVDAAPT, SEQ ID NO: 1163 RCPLGDRLNVEVDTAPT, SEQ ID NO: 1164 RSQLGDRLNVEVDAAPT, SEQ ID NO: 1165 RSQLGDRLNVEVDTAPT, SEQ ID NO: 1166 RSPLGDRLNVEVDAAPT, SEQ ID NO: 1167 RSPLGDRLNVEVDTAPT, SEQ ID NO: 1168 CQLGDRLNVEVDAAPTV, SEQ ID NO: 1169 CQLGDRLNVEVDTAPTV, SEQ ID NO: 1170 CPLGDRLNVEVDAAPTV, SEQ ID NO: 1171 CPLGDRLNVEVDTAPTV, SEQ ID NO: 1172 SQLGDRLNVEVDAAPTV, SEQ ID NO: 1173 SQLGDRLNVEVDTAPTV, SEQ ID NO: 1174 SPLGDRLNVEVDAAPTV, SEQ ID NO: 1175 SPLGDRLNVEVDTAPTV, SEQ ID NO: 1176 QLGDRLNVEVDAAPTVD, SEQ ID NO: 1177 QLGDRLNVEVDTAPTVD, SEQ ID NO: 1178 PLGDRLNVEVDAAPTVD, SEQ ID NO: 1179 PLGDRLNVEVDTAPTVD, SEQ ID NO: 1180 LGDRLNVEVDAAPTVDL, SEQ ID NO: 1181 LGDRLNVEVDTAPTVDL, SEQ ID NO: 1182 GDRLNVEVDAAPTVDLN, SEQ ID NO: 1183 GDRLNVEVDTAPTVDLN, SEQ ID NO: 1184 DRLNVEVDAAPTVDLNQ, SEQ ID NO: 1185 DRLNVEVDAAPTVDLNR, SEQ ID NO: 1186 DRLNVEVDTAPTVDLNQ, SEQ ID NO: 1187 DRLNVEVDTAPTVDLNR, SEQ ID NO: 1188 RLNVEVDAAPTVDLNQV, SEQ ID NO: 1189 RLNVEVDAAPTVDLNQV, SEQ ID NO: 1190 RLNVEVDTAPTVDLNQV, SEQ ID NO: 1191 RLNVEVDTAPTVDLNRV, SEQ ID NO: 1192 LNVEVDAAPTVDLNQVL, SEQ ID NO: 1193 LNVEVDAAPTVDLNRVL, SEQ ID NO: 1194 LNVEVDTAPTVDLNQVL, SEQ ID NO: 1195 LNVEVDTAPTVDLNRVL, SEQ ID NO: 1196 NVEVDAAPTVDLNQVLN, SEQ ID NO: 1197 NVEVDAAPTVDLNRVLN, SEQ ID NO: 1198 NVEVDTAPTVDLNQVLN, SEQ ID NO: 1199 NVEVDTAPTVDLNRVLN, SEQ ID NO: 1200 VEVDAAPTVDLNQVLNE, SEQ ID NO: 1201 VEVDAAPTVDLNRVLNE, SEQ ID NO: 1202 VEVDTAPTVDLNQVLNE, SEQ ID NO: 1203 VEVDTAPTVDLNRVLNE, SEQ ID NO: 1204 EVDAAPTVDLNQVLNET, SEQ ID NO: 1205 EVDAAPTVDLNRVLNET, SEQ ID NO: 1206 EVDTAPTVDLNQVLNET, SEQ ID NO: 1207 EVDTAPTVDLNRVLNET, SEQ ID NO: 1208 VDAAPTVDLNQVLNETR, SEQ ID NO: 1209 VDAAPTVDLNRVLNETR, SEQ ID NO: 1210 VDTAPTVDLNQVLNETR, SEQ ID NO: 1211 VDTAPTVDLNRVLNETR, SEQ ID NO: 1212 DAAPTVDLNQVLNETRS, SEQ ID NO: 1213 DAAPTVDLNQVLNETRN, SEQ ID NO: 1214 DAAPTVDLNRVLNETRS, SEQ ID NO: 1215 DTAPTVDLNRVLNETRN, SEQ ID NO: 1216 DTAPTVDLNQVLNETRS, SEQ ID NO: 1217 DTAPTVDLNQVLNETRN, SEQ ID NO: 1218 DTAPTVDLNRVLNETRS, SEQ ID NO: 1219 DTAPTVDLNRVLNETRN, SEQ ID NO: 1220 AAPTVDLNQVLNETRSQ, SEQ ID NO: 1221 AAPTVDLNQVLNETRNQ, SEQ ID NO: 1222 AAPTVDLNRVLNETRSQ, SEQ ID NO: 1223 AAPTVDLNRVLNETRNQ, SEQ ID NO: 1224 TAPTVDLNQVLNETRSQ, SEQ ID NO: 1225 TAPTVDLNQVLNETRNQ, SEQ ID NO: 1226 TAPTVDLNRVLNETRSQ, SEQ ID NO: 1227 TAPTVDLNRVLNETRNQ, SEQ ID NO: 1228 APTVDLNQVLNETRSQY, SEQ ID NO: 1229 APTVDLNQVLNETRNQY, SEQ ID NO: 1230 APTVDLNRVLNETRSQY, SEQ ID NO: 1231 APTVDLNRVLNETRNQY, SEQ ID NO: 1232 PTVDLNQVLNETRSQYE, SEQ ID NO: 1233 PTVDLNQVLNETRNQYE, SEQ ID NO: 1234 PTVDLNRVLNETRSQYE, SEQ ID NO: 1235 PTVDLNRVLNETRNQYE, SEQ ID NO: 1236 TVDLNQVLNETRSQYEA, SEQ ID NO: 1237 TVDLNQVLNETRNQYEA, SEQ ID NO: 1238 TVDLNRVLNETRSQYEA, SEQ ID NO: 1239 TVDLNRVLNETRNQYEA, SEQ ID NO: 1240 VDLNQVLNETRSQYEAL, SEQ ID NO: 1241 VDLNQVLNETRNQYEAL, SEQ ID NO: 1242 VDLNRVLNETRSQYEAL, SEQ ID NO: 1243 VDLNRVLNETRNQYEAL, SEQ ID NO: 1244 EVNTLRCQLGDRLNVEVD, SEQ ID NO: 1245 EVNTLRCPLGDRLNVEVD, SEQ ID NO: 1246 EVNTLRSQLGDRLNVEVD, SEQ ID NO: 1247 EVNTLRSPLGDRLNVEVD, SEQ ID NO: 1248 VNTLRCQLGDRLNVEVDA, SEQ ID NO: 1249 VNTLRCQLGDRLNVEVDT, SEQ ID NO: 1250 VNTLRCPLGDRLNVEVDA, SEQ ID NO: 1251 VNTLRCPLGDRLNVEVDT, SEQ ID NO: 1252 VNTLRSQLGDRLNVEVDA, SEQ ID NO: 1253 VNTLRSQLGDRLNVEVDT, SEQ ID NO: 1254 VNTLRSPLGDRLNVEVDA, SEQ ID NO: 1255 VNTLRSPLGDRLNVEVDT, SEQ ID NO: 1256 NTLRCQLGDRLNVEVDAA, SEQ ID NO: 1257 NTLRCQLGDRLNVEVDTA, SEQ ID NO: 1258 NTLRCPLGDRLNVEVDAA, SEQ ID NO: 1259 NTLRCPLGDRLNVEVDTA, SEQ ID NO: 1260 NTLRSQLGDRLNVEVDAA, SEQ ID NO: 1261 NTLRSQLGDRLNVEVDTA, SEQ ID NO: 1262 NTLRSPLGDRLNVEVDAA, SEQ ID NO: 1263 NTLRSPLGDRLNVEVDTA, SEQ ID NO: 1264 TLRCQLGDRLNVEVDAAP, SEQ ID NO: 1265 TLRCQLGDRLNVEVDTAP, SEQ ID NO: 1266 TLRCPLGDRLNVEVDAAP, SEQ ID NO: 1267 TLRCPLGDRLNVEVDTAP, SEQ ID NO: 1268 TLRSQLGDRLNVEVDAAP, SEQ ID NO: 1269 TLRSQLGDRLNVEVDTAP, SEQ ID NO: 1270 TLRSPLGDRLNVEVDAAP, SEQ ID NO: 1271 TLRSPLGDRLNVEVDTAP, SEQ ID NO: 1272 LRCQLGDRLNVEVDAAPT, SEQ ID NO: 1273 LRCQLGDRLNVEVDTAPT, SEQ ID NO: 1274 LRCPLGDRLNVEVDAAPT, SEQ ID NO: 1275 LRCPLGDRLNVEVDTAPT, SEQ ID NO: 1276 LRSQLGDRLNVEVDAAPT, SEQ ID NO: 1277 LRSQLGDRLNVEVDTAPT, SEQ ID NO: 1278 LRSPLGDRLNVEVDAAPT, SEQ ID NO: 1279 LRSPLGDRLNVEVDTAPT, SEQ ID NO: 1280 RCQLGDRLNVEVDAAPTV, SEQ ID NO: 1281 RCQLGDRLNVEVDTAPTV, SEQ ID NO: 1282 RCPLGDRLNVEVDAAPTV, SEQ ID NO: 1283 RCPLGDRLNVEVDTAPTV, SEQ ID NO: 1284 RSQLGDRLNVEVDAAPTV, SEQ ID NO: 1285 RSQLGDRLNVEVDTAPTV, SEQ ID NO: 1286 RSPLGDRLNVEVDAAPTV, SEQ ID NO: 1287 RSPLGDRLNVEVDTAPTV, SEQ ID NO: 1288 CQLGDRLNVEVDAAPTVD, SEQ ID NO: 1289 CQLGDRLNVEVDTAPTVD, SEQ ID NO: 1290 CPLGDRLNVEVDAAPTVD, SEQ ID NO: 1291 CPLGDRLNVEVDTAPTVD, SEQ ID NO: 1292 SQLGDRLNVEVDAAPTVD, SEQ ID NO: 1293 SQLGDRLNVEVDTAPTVD, SEQ ID NO: 1294 SPLGDRLNVEVDAAPTVD, SEQ ID NO: 1295 SPLGDRLNVEVDTAPTVD, SEQ ID NO: 1296 QLGDRLNVEVDAAPTVDL, SEQ ID NO: 1297 QLGDRLNVEVDTAPTVDL, SEQ ID NO: 1298 PLGDRLNVEVDAAPTVDL, SEQ ID NO: 1299 PLGDRLNVEVDTAPTVDL, SEQ ID NO: 1300 LGDRLNVEVDAAPTVDLN, SEQ ID NO: 1301 LGDRLNVEVDTAPTVDLN, SEQ ID NO: 1302 GDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1303 GDRLNVEVDAAPTVDLNR, SEQ ID NO: 1304 GDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1305 GDRLNVEVDTAPTVDLNR, SEQ ID NO: 1306 DRLNVEVDAAPTVDLNQV, SEQ ID NO: 1307 DRLNVEVDAAPTVDLNRV, SEQ ID NO: 1308 DRLNVEVDTAPTVDLNQV, SEQ ID NO: 1309 DRLNVEVDTAPTVDLNRV, SEQ ID NO: 1310 RLNVEVDAAPTVDLNQVL, SEQ ID NO: 1311 RLNVEVDAAPTVDLNRVL, SEQ ID NO: 1312 RLNVEVDTAPTVDLNQVL, SEQ ID NO: 1313 RLNVEVDTAPTVDLNRVL, SEQ ID NO: 1314 LNVEVDAAPTVDLNQVLN, SEQ ID NO: 1315 LNVEVDAAPTVDLNRVLN, SEQ ID NO: 1316 LNVEVDTAPTVDLNQVLN, SEQ ID NO: 1317 LNVEVDTAPTVDLNRVLN, SEQ ID NO: 1318 NVEVDAAPTVDLNQVLNE, SEQ ID NO: 1319 NVEVDAAPTVDLNRVLNE, SEQ ID NO: 1320 NVEVDTAPTVDLNQVLNE, SEQ ID NO: 1321 NVEVDTAPTVDLNRVLNE, SEQ ID NO: 1322 VEVDAAPTVDLNQVLNET, SEQ ID NO: 1323 VEVDAAPTVDLNRVLNET, SEQ ID NO: 1324 VEVDTAPTVDLNQVLNET, SEQ ID NO: 1325 VEVDTAPTVDLNRVLNET, SEQ ID NO: 1326 EVDAAPTVDLNQVLNETR, SEQ ID NO: 1327 EVDAAPTVDLNRVLNETR, SEQ ID NO: 1328 EVDTAPTVDLNQVLNETR, SEQ ID NO: 1329 EVDTAPTVDLNRVLNETR, SEQ ID NO: 1330 VDAAPTVDLNQVLNETRS, SEQ ID NO: 1331 VDAAPTVDLNQVLNETRN, SEQ ID NO: 1332 VDAAPTVDLNRVLNETRS, SEQ ID NO: 1333 VDAAPTVDLNRVLNETRN, SEQ ID NO: 1334 VDTAPTVDLNQVLNETRS, SEQ ID NO: 1335 VDTAPTVDLNQVLNETRN, SEQ ID NO: 1336 VDTAPTVDLNRVLNETRS, SEQ ID NO: 1337 VDTAPTVDLNRVLNETRN, SEQ ID NO: 1338 DAAPTVDLNQVLNETRSQ, SEQ ID NO: 1339 DAAPTVDLNQVLNETRNQ, SEQ ID NO: 1340 DAAPTVDLNRVLNETRSQ, SEQ ID NO: 1341 DAAPTVDLNRVLNETRNQ, SEQ ID NO: 1342 DTAPTVDLNQVLNETRSQ, SEQ ID NO: 1343 DTAPTVDLNQVLNETRNQ, SEQ ID NO: 1344 DTAPTVDLNRVLNETRSQ, SEQ ID NO: 1345 DTAPTVDLNRVLNETRNQ, SEQ ID NO: 1346 AAPTVDLNQVLNETRNQY, SEQ ID NO: 1347 AAPTVDLNQVLNETRNQY, SEQ ID NO: 1348 AAPTVDLNRVLNETRSQY, SEQ ID NO: 1349 AAPTVDLNRVLNETRNQY, SEQ ID NO: 1350 TAPTVDLNQVLNETRSQY, SEQ ID NO: 1351 TAPTVDLNQVLNETRNQY, SEQ ID NO: 1352 TAPTVDLNRVLNETRSQY, SEQ ID NO: 1353 TAPTVDLNRVLNETRNQY, SEQ ID NO: 1354 APTVDLNQVLNETRSQYE, SEQ ID NO: 1355 APTVDLNQVLNETRNQYE, SEQ ID NO: 1356 APTVDLNRVLNETRSQYE, SEQ ID NO: 1357 APTVDLNRVLNETRNQYE, SEQ ID NO: 1358 PTVDLNQVLNETRSQYEA, SEQ ID NO: 1359 PTVDLNQVLNETRSQYEA, SEQ ID NO: 1360 PTVDLNRVLNETRSQYEA, SEQ ID NO: 1361 PTVDLNRVLNETRNQYEA, SEQ ID NO: 1362 TVDLNQVLNETRSQYEAL, SEQ ID NO: 1363 TVDLNQVLNETRNQYEAL, SEQ ID NO: 1364 TVDLNRVLNETRSQYEAL, SEQ ID NO: 1365 TVDLNRVLNETRNQYEAL, SEQ ID NO: 1366 EVNTLRCQLGDRLNVEVDA, SEQ ID NO: 1367 EVNTLRCQLGDRLNVEVDT, SEQ ID NO: 1368 EVNTLRCPLGDRLNVEVDA, SEQ ID NO: 1369 EVNTLRCPLGDRLNVEVDT, SEQ ID NO: 1370 EVNTLRSQLGDRLNVEVDA, SEQ ID NO: 1371 EVNTLRSQLGDRLNVEVDT, SEQ ID NO: 1372 EVNTLRSPLGDRLNVEVDA, SEQ ID NO: 1373 EVNTLRSPLGDRLNVEVDT, SEQ ID NO: 1374 VNTLRCQLGDRLNVEVDAA, SEQ ID NO: 1375 VNTLRCQLGDRLNVEVDTA, SEQ ID NO: 1376 VNTLRCPLGDRLNVEVDAA, SEQ ID NO: 1377 VNTLRCPLGDRLNVEVDTA, SEQ ID NO: 1378 VNTLRSQLGDRLNVEVDAA, SEQ ID NO: 1379 VNTLRSQLGDRLNVEVDTA, SEQ ID NO: 1380 VNTLRSPLGDRLNVEVDAA, SEQ ID NO: 1381 VNTLRSPLGDRLNVEVDTA, SEQ ID NO: 1382 VNTLRCQLGDRLNVEVDAA, SEQ ID NO: 1383 VNTLRCQLGDRLNVEVDTA, SEQ ID NO: 1384 VNTLRCPLGDRLNVEVDAA, SEQ ID NO: 1385 VNTLRCPLGDRLNVEVDTA, SEQ ID NO: 1386 VNTLRSQLGDRLNVEVDAA, SEQ ID NO: 1387 VNTLRSQLGDRLNVEVDTA, SEQ ID NO: 1388 VNTLRSPLGDRLNVEVDAA, SEQ ID NO: 1389 VNTLRSPLGDRLNVEVDTA, SEQ ID NO: 1390 TLRCQLGDRLNVEVDAAPT, SEQ ID NO: 1391 TLRCQLGDRLNVEVDTAPT, SEQ ID NO: 1392 TLRCPLGDRLNVEVDAAPT, SEQ ID NO: 1393 TLRCPLGDRLNVEVDTAPT, SEQ ID NO: 1394 TLRSQLGDRLNVEVDAAPT, SEQ ID NO: 1395 TLRSQLGDRLNVEVDTAPT, SEQ ID NO: 1396 TLRSPLGDRLNVEVDAAPT, SEQ ID NO: 1397 TLRSPLGDRLNVEVDTAPT, SEQ ID NO: 1398 LRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1399 LRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1400 LRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1401 LRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1402 LRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1403 LRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1404 LRSPLGDRLNVEVDAAPTV, SEQ ID NO: 1405 LRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1406 LRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1407 LRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1408 LRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1409 LRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1410 LRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1411 LRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1412 LRSPLGDRLNVEVDAAPTV, SEQ ID NO: 1413 LRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1414 LRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1415 LRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1416 LRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1417 LRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1418 LRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1419 LRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1420 LRSPLGDRLNVEVDAAPTV, SEQ ID NO: 1421 LRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1422 QLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1423 QLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1424 PLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1425 PLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1426 LGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1427 LGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1428 LGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1429 LGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1430 GDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1431 GDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1432 GDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1433 GDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1434 DRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1435 DRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1436 DRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1437 DRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1438 RLNVEVDAAPTVDLNQVLN, SEQ ID NO: 1439 RLNVEVDAAPTVDLNRVLN, SEQ ID NO: 1440 RLNVEVDTAPTVDLNQVLN, SEQ ID NO: 1441 RLNVEVDTAPTVDLNRVLN, SEQ ID NO: 1442 LNVEVDAAPTVDLNQVLNE, SEQ ID NO: 1443 LNVEVDAAPTVDLNRVLNE, SEQ ID NO: 1444 LNVEVDTAPTVDLNQVLNE, SEQ ID NO: 1445 LNVEVDTAPTVDLNRVLNE, SEQ ID NO: 1446 NVEVDAAPTVDLNQVLNET, SEQ ID NO: 1447 NVEVDAAPTVDLNRVLNET, SEQ ID NO: 1448 NVEVDTAPTVDLNQVLNET, SEQ ID NO: 1449 NVEVDTAPTVDLNRVLNET, SEQ ID NO: 1450 VEVDAAPTVDLNQVLNETR, SEQ ID NO: 1451 VEVDAAPTVDLNRVLNETR, SEQ ID NO: 1452 VEVDTAPTVDLNQVLNETR, SEQ ID NO: 1453 VEVDTAPTVDLNRVLNETR, SEQ ID NO: 1454 EVDAAPTVDLNQVLNETRS, SEQ ID NO: 1455 EVDAAPTVDLNQVLNETRN, SEQ ID NO: 1456 EVDAAPTVDLNRVLNETRS, SEQ ID NO: 1457 EVDAAPTVDLNRVLNETRN, SEQ ID NO: 1458 EVDTAPTVDLNQVLNETRS, SEQ ID NO: 1459 EVDTAPTVDLNQVLNETRN, SEQ ID NO: 1460 EVDTAPTVDLNRVLNETRS, SEQ ID NO: 1461 EVDTAPTVDLNRVLNETRN, SEQ ID NO: 1462 VDAAPTVDLNQVLNETRSQ, SEQ ID NO: 1463 VDAAPTVDLNQVLNETRNQ, SEQ ID NO: 1464 VDAAPTVDLNRVLNETRSQ, SEQ ID NO: 1465 VDAAPTVDLNRVLNETRNQ, SEQ ID NO: 1466 VDTAPTVDLNQVLNETRSQ, SEQ ID NO: 1467 VDTAPTVDLNQVLNETRNQ, SEQ ID NO: 1468 VDTAPTVDLNRVLNETRSQ, SEQ ID NO: 1469 VDTAPTVDLNRVLNETRNQ, SEQ ID NO: 1470 DAAPTVDLNQVLNETRSQY, SEQ ID NO: 1471 DAAPTVDLNQVLNETRNQY, SEQ ID NO: 1472 DAAPTVDLNRVLNETRSQY, SEQ ID NO: 1473 DAAPTVDLNRVLNETRNQY, SEQ ID NO: 1474 DTAPTVDLNQVLNETRSQY, SEQ ID NO: 1475 DTAPTVDLNQVLNETRNQY, SEQ ID NO: 1476 DTAPTVDLNRVLNETRSQY, SEQ ID NO: 1477 DTAPTVDLNRVLNETRNQY, SEQ ID NO: 1478 AAPTVDLNQVLNETRSQYE, SEQ ID NO: 1479 AAPTVDLNQVLNETRNQYE, SEQ ID NO: 1480 AAPTVDLNRVLNETRSQYE, SEQ ID NO: 1481 AAPTVDLNRVLNETRNQYE, SEQ ID NO: 1482 TAPTVDLNQVLNETRSQYE, SEQ ID NO: 1483 TAPTVDLNQVLNETRNQYE, SEQ ID NO: 1484 TAPTVDLNRVLNETRSQYE, SEQ ID NO: 1485 TAPTVDLNRVLNETRNQYE, SEQ ID NO: 1486 APTVDLNQVLNETRSQYEA, SEQ ID NO: 1487 APTVDLNQVLNETRNQYEA, SEQ ID NO: 1488 APTVDLNRVLNETRSQYEA, SEQ ID NO: 1489 APTVDLNRVLNETRNQYEA, SEQ ID NO: 1490 PTVDLNQVLNETRNQYEAL, SEQ ID NO: 1491 PTVDLNQVLNETRNQYEAL, SEQ ID NO: 1492 PTVDLNRVLNETRSQYEAL, SEQ ID NO: 1493 PTVDLNRVLNETRNQYEAL, SEQ ID NO: 1494 EVNTLRCQLGDRLNVEVDAA, SEQ ID NO: 1495 EVNTLRCQLGDRLNVEVDTA, SEQ ID NO: 1496 EVNTLRCPLGDRLNVEVDAA, SEQ ID NO: 1497 EVNTLRCPLGDRLNVEVDTA, SEQ ID NO: 1498 EVNTLRSQLGDRLNVEVDAA, SEQ ID NO: 1499 EVNTLRSQLGDRLNVEVDTA, SEQ ID NO: 1500 EVNTLRSPLGDRLNVEVDAA, SEQ ID NO: 1501 EVNTLRSPLGDRLNVEVDTA, SEQ ID NO: 1502 VNTLRCQLGDRLNVEVDAAP, SEQ ID NO: 1503 VNTLRCQLGDRLNVEVDTAP, SEQ ID NO: 1504 VNTLRCPLGDRLNVEVDAAP, SEQ ID NO: 1505 VNTLRCPLGDRLNVEVDTAP, SEQ ID NO: 1506 VNTLRSQLGDRLNVEVDAAP, SEQ ID NO: 1507 VNTLRSQLGDRLNVEVDTAP, SEQ ID NO: 1508 VNTLRSPLGDRLNVEVDAAP, SEQ ID NO: 1509 VNTLRSPLGDRLNVEVDTAP, SEQ ID NO: 1510 NTLRCQLGDRLNVEVDAAPT, SEQ ID NO: 1511 NTLRCQLGDRLNVEVDTAPT, SEQ ID NO: 1512 NTLRCPLGDRLNVEVDAAPT, SEQ ID NO: 1513 NTLRCPLGDRLNVEVDTAPT, SEQ ID NO: 1514 NTLRSQLGDRLNVEVDAAPT, SEQ ID NO: 1515 NTLRSQLGDRLNVEVDTAPT, SEQ ID NO: 1516 NTLRSPLGDRLNVEVDAAPT, SEQ ID NO: 1517 NTLRSPLGDRLNVEVDTAPT, SEQ ID NO: 1518 TLRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1519 TLRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1520 TLRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1521 TLRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1522 TLRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1523 TLRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1524 TLRSPLGDRLNVEVDAAPTV, SEQ ID NO: 1525 TLRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1526 LRCQLGDRLNVEVDAAPTVD, SEQ ID NO: 1527 LRCQLGDRLNVEVDTAPTVD, SEQ ID NO: 1528 LRCPLGDRLNVEVDAAPTVD, SEQ ID NO: 1529 LRCPLGDRLNVEVDTAPTVD, SEQ ID NO: 1530 LRSQLGDRLNVEVDAAPTVD, SEQ ID NO: 1531 LRSQLGDRLNVEVDTAPTVD, SEQ ID NO: 1532 LRSPLGDRLNVEVDAAPTVD, SEQ ID NO: 1533 LRSPLGDRLNVEVDTAPTVD, SEQ ID NO: 1534 RCQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1535 RCQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1536 RCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1537 RCPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1538 RSQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1539 RSQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1540 RSPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1541 RSPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1542 CQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1543 CQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1544 CPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1545 CPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1546 SQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1547 SQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1548 SPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1549 SPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1550 QLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1551 QLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1552 QLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1553 QLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1554 PLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1555 PLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1556 PLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1557 PLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1558 LGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1559 LGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1560 LGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1561 LGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1562 GDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1563 GDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1564 GDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1565 GDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1566 DRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 1567 DRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 1568 DRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 1569 DRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 1570 RLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 1571 RLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 1572 RLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 1573 RLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 1574 LNVEVDAAPTVDLNQVLNET, SEQ ID NO: 1575 LNVEVDAAPTVDLNRVLNET, SEQ ID NO: 1576 LNVEVDTAPTVDLNQVLNET, SEQ ID NO: 1577 LNVEVDTAPTVDLNRVLNET, SEQ ID NO: 1578 NVEVDAAPTVDLNQVLNETR, SEQ ID NO: 1579 NVEVDAAPTVDLNRVLNETR, SEQ ID NO: 1580 NVEVDTAPTVDLNQVLNETR, SEQ ID NO: 1581 NVEVDTAPTVDLNRVLNETR, SEQ ID NO: 1582 VEVDAAPTVDLNQVLNETRS, SEQ ID NO: 1583 VEVDAAPTVDLNQVLNETRN, SEQ ID NO: 1584 VEVDAAPTVDLNRVLNETRS, SEQ ID NO: 1585 VEVDAAPTVDLNRVLNETRN, SEQ ID NO: 1586 VEVDTAPTVDLNQVLNETRS, SEQ ID NO: 1587 VEVDTAPTVDLNQVLNETRN, SEQ ID NO: 1588 VEVDTAPTVDLNRVLNETRS, SEQ ID NO: 1589 VEVDTAPTVDLNRVLNETRN, SEQ ID NO: 1590 EVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 1591 EVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 1592 EVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 1593 EVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 1594 EVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 1595 EVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 1596 EVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 1597 EVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 1598 VDAAPTVDLNQVLNETRSQY, SEQ ID NO: 1599 VDAAPTVDLNQVLNETRNQY, SEQ ID NO: 1600 VDAAPTVDLNRVLNETRSQY, SEQ ID NO: 1601 VDAAPTVDLNRVLNETRNQY, SEQ ID NO: 1602 VDTAPTVDLNQVLNETRSQY, SEQ ID NO: 1603 VDTAPTVDLNQVLNETRNQY, SEQ ID NO: 1604 VDTAPTVDLNRVLNETRSQY, SEQ ID NO: 1605 VDTAPTVDLNRVLNETRSQY, SEQ ID NO: 1606 DAAPTVDLNQVLNETRSQYE, SEQ ID NO: 1607 DAAPTVDLNQVLNETRNQYE, SEQ ID NO: 1608 DAAPTVDLNRVLNETRSQYE, SEQ ID NO: 1609 DAAPTVDLNRVLNETRNQYE, SEQ ID NO: 1610 DTAPTVDLNQVLNETRSQYE, SEQ ID NO: 1611 DTAPTVDLNQVLNETRNQYE, SEQ ID NO: 1612 DTAPTVDLNRVLNETRSQYE, SEQ ID NO: 1613 DTAPTVDLNRVLNETRNQYE, SEQ ID NO: 1614 AAPTVDLNQVLNETRSQYEA, SEQ ID NO: 1615 AAPTVDLNQVLNETRNQYEA, SEQ ID NO: 1616 AAPTVDLNRVLNETRSQYEA, SEQ ID NO: 1617 AAPTVDLNRVLNETRNQYEA, SEQ ID NO: 1618 TAPTVDLNQVLNETRSQYEA, SEQ ID NO: 1619 TAPTVDLNQVLNETRNQYEA, SEQ ID NO: 1620 TAPTVDLNRVLNETRSQYEA, SEQ ID NO: 1621 TAPTVDLNRVLNETRNQYEA, SEQ ID NO: 1622 APTVDLNQVLNETRSQYEAL, SEQ ID NO: 1623 APTVDLNQVLNETRNQYEAL, SEQ ID NO: 1624 APTVDLNRVLNETRSQYEAL, SEQ ID NO: 1625 APTVDLNRVLNETRNQYEAL, SEQ ID NO: 1626 EVNTLRCQLGDRLNVEVDAAP, SEQ ID NO: 1627 EVNTLRCQLGDRLNVEVDTAP, SEQ ID NO: 1628 EVNTLRCPLGDRLNVEVDAAP, SEQ ID NO: 1629 EVNTLRCPLGDRLNVEVDTAP, SEQ ID NO: 1630 EVNTLRSQLGDRLNVEVDAAP, SEQ ID NO: 1631 EVNTLRSQLGDRLNVEVDTAP, SEQ ID NO: 1632 EVNTLRSPLGDRLNVEVDAAP, SEQ ID NO: 1633 EVNTLRSPLGDRLNVEVDTAP, SEQ ID NO: 1634 VNTLRCQLGDRLNVEVDAAPT, SEQ ID NO: 1635 VNTLRCQLGDRLNVEVDTAPT, SEQ ID NO: 1636 VNTLRCPLGDRLNVEVDAAPT, SEQ ID NO: 1637 VNTLRCPLGDRLNVEVDTAPT, SEQ ID NO: 1638 VNTLRSQLGDRLNVEVDAAPT, SEQ ID NO: 1639 VNTLRSQLGDRLNVEVDTAPT, SEQ ID NO: 1640 VNTLRSPLGDRLNVEVDAAPT, SEQ ID NO: 1641 VNTLRSPLGDRLNVEVDTAPT, SEQ ID NO: 1642 NTLRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1643 NTLRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1644 NTLRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1645 NTLRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1646 NTLRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1647 NTLRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1648 NTLRSPLGDRLNVEVDAAPTV, SEQ ID NO: 1649 NTLRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1650 TLRCQLGDRLNVEVDAAPTVD, SEQ ID NO: 1651 TLRCQLGDRLNVEVDTAPTVD, SEQ ID NO: 1652 TLRCPLGDRLNVEVDAAPTVD, SEQ ID NO: 1653 TLRCPLGDRLNVEVDTAPTVD, SEQ ID NO: 1654 TLRSQLGDRLNVEVDAAPTVD, SEQ ID NO: 1655 TLRSQLGDRLNVEVDTAPTVD, SEQ ID NO: 1656 TLRSPLGDRLNVEVDAAPTVD, SEQ ID NO: 1657 TLRSPLGDRLNVEVDTAPTVD, SEQ ID NO: 1658 LRCQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1659 LRCQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1660 LRCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1661 LRCPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1662 LRSQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1663 LRSQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1664 LRCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1665 LRSPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1666 RCQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1667 RCQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1668 RCPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1669 RCPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1670 RSQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1671 RSQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1672 RSPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1673 RSPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1674 CQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1675 SQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1676 CPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1677 SPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1678 CQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1679 SQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1680 CPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1681 SPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1682 CQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1683 SQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1684 CPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1685 SPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1686 CQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1687 SQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1688 CPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1689 SPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1690 QLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1691 QLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1692 QLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1693 QLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1694 PLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1695 PLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1696 PLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1697 PLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1698 LGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1699 LGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1700 LGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1701 LGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1702 GDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 1703 GDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 1704 GDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 1705 GDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 1706 DRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 1707 DRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 1708 DRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 1709 DRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 1710 RLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 1711 RLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 1712 RLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 1713 RLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 1714 LNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 1715 LNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 1716 LNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 1717 LNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 1718 NVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 1719 NVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 1720 NVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 1721 NVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 1722 NVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 1723 NVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 1724 NVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 1725 NVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 1726 VEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 1727 VEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 1728 VEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 1729 VEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 1730 VEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 1731 VEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 1732 VEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 1733 VEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 1734 EVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 1735 EVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 1736 EVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 1737 EVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 1738 EVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 1739 EVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 1740 EVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 1741 EVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 1742 VDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 1743 VDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 1744 VDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 1745 VDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 1746 VDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 1747 VDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 1748 VDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 1749 VDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 1750 DAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 1751 DAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 1752 DAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 1753 DAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 1754 DTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 1755 DTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 1756 DTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 1757 DTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 1758 AAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 1759 AAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 1760 AAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 1761 AAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 1762 TAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 1763 TAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 1764 TAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 1765 TAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 1766 EVNTLRCQLGDRLNVEVDAAPT, SEQ ID NO: 1767 EVNTLRCQLGDRLNVEVDTAPT, SEQ ID NO: 1768 EVNTLRCPLGDRLNVEVDAAPT, SEQ ID NO: 1769 EVNTLRCPLGDRLNVEVDTAPT, SEQ ID NO: 1770 EVNTLRSQLGDRLNVEVDAAPT, SEQ ID NO: 1771 EVNTLRSQLGDRLNVEVDTAPT, SEQ ID NO: 1772 EVNTLRSPLGDRLNVEVDAAPT, SEQ ID NO: 1773 EVNTLRSPLGDRLNVEVDTAPT, SEQ ID NO: 1774 VNTLRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1775 VNTLRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1776 VNTLRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1777 VNTLRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1778 VNTLRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1779 VNTLRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1780 VNTLRSPLGDRLNVEVDAAPTV, SEQ ID NO: 1781 VNTLRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1782 NTLRCQLGDRLNVEVDAAPTVD, SEQ ID NO: 1783 NTLRCQLGDRLNVEVDTAPTVD, SEQ ID NO: 1784 NTLRCPLGDRLNVEVDAAPTVD, SEQ ID NO: 1785 NTLRCPLGDRLNVEVDTAPTVD, SEQ ID NO: 1786 NTLRSQLGDRLNVEVDAAPTVD, SEQ ID NO: 1787 NTLRSQLGDRLNVEVDTAPTVD, SEQ ID NO: 1788 NTLRSPLGDRLNVEVDAAPTVD, SEQ ID NO: 1789 NTLRSPLGDRLNVEVDTAPTVD, SEQ ID NO: 1790 TLRCQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1791 TLRCQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1792 TLRCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1793 TLRCPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1794 TLRSQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1795 TLRSQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1796 TLRSPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1797 TLRSPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1798 LRCQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1799 LRCQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1800 LRCPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1801 LRCPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1802 LRSQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1803 LRSQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1804 LRSPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 11805 LRSPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1806 RCQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1807 RSQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1808 RCPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1809 RSPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1810 RCQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1811 RSQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1812 RCPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1813 RSPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1814 RCQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1815 RSQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1816 RCPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1817 RSPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1818 RCQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1819 RSQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1820 RCPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1821 RSPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1822 CQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1823 SQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1824 CPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1825 SPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1826 CQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1827 SQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1828 CPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1829 SPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1830 CQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1831 SQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1832 CPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1833 SPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1834 CQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1835 SQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1836 CPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1837 SPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1838 QLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1839 QLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1840 QLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1841 QLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1842 PLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1843 PLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1844 PLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1845 PLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1846 LGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 1847 LGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 1848 LGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 1849 LGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 1850 GDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 1851 GDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 1852 GDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 1853 GDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 1854 DRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 1855 DRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 1856 DRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 1857 DRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 1858 RLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 1859 RLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 1860 RLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 1861 RLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 1862 LNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 1863 LNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 1864 LNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 1865 LNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 1866 LNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 1867 LNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 1868 LNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 1869 LNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 1870 NVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 1871 NVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 1872 NVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 1873 NVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 1874 NVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 1875 NVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 1876 NVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 1877 NVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 1878 EVNTLRCQLGDRLNVEVDAAPTV, SEQ ID NO: 1879 EVNTLRCQLGDRLNVEVDTAPTV, SEQ ID NO: 1880 EVNTLRCPLGDRLNVEVDAAPTV, SEQ ID NO: 1881 EVNTLRCPLGDRLNVEVDTAPTV, SEQ ID NO: 1882 EVNTLRSQLGDRLNVEVDAAPTV, SEQ ID NO: 1883 EVNTLRSQLGDRLNVEVDTAPTV, SEQ ID NO: 1884 EVNTLRSPLGDRLNVEVDAAPTV, SEQ ID NO: 11885 EVNTLRSPLGDRLNVEVDTAPTV, SEQ ID NO: 1886 VNTLRCQLGDRLNVEVDAAPTVD, SEQ ID NO: 1887 VNTLRSQLGDRLNVEVDAAPTVD, SEQ ID NO: 1888 VNTLRCPLGDRLNVEVDAAPTVD, SEQ ID NO: 1889 VNTLRSPLGDRLNVEVDAAPTVD, SEQ ID NO: 1890 VNTLRCQLGDRLNVEVDTAPTVD, SEQ ID NO: 1891 VNTLRSQLGDRLNVEVDTAPTVD, SEQ ID NO: 1892 VNTLRCPLGDRLNVEVDTAPTVD, SEQ ID NO: 1893 VNTLRSPLGDRLNVEVDTAPTVD, SEQ ID NO: 1894 NTLRCQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1895 NTLRSQLGDRLNVEVDAAPTVDL, SEQ ID NO: 1896 NTLRCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1897 NTLRSPLGDRLNVEVDAAPTVDL, SEQ ID NO: 1898 NTLRCQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1899 NTLRSQLGDRLNVEVDTAPTVDL, SEQ ID NO: 1900 NTLRCPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1901 NTLRSPLGDRLNVEVDTAPTVDL, SEQ ID NO: 1902 TLRCQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1903 TLRSQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1904 TLRCPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1905 TLRSPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 1906 TLRCQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1907 TLRSQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1908 TLRCPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1909 TLRSPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 1910 LRCQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1911 LRSQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1912 LRCPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1913 LRSPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 1914 LRCQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1915 LRSQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1916 LRCPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1917 LRSPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 1918 LRCQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1919 LRSQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1920 LRCPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1921 LRSPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 1922 LRCQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1923 LRSQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1924 LRCPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1925 LRSPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 1926 RCQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1927 RSQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1928 RCPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1929 RSPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 1930 RCQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1931 RSQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1932 RCPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1933 RSPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 1934 RCQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1935 RSQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1936 RCPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1937 RSPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 1938 RCQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1939 RSQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1940 RCPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1941 RSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 1942 CQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1943 SQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1944 CPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1945 SPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 1946 CQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1947 SQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1948 CPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1949 SPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 1950 CQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1951 SQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1952 CPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1953 SPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 1954 CQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1955 SQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1956 CPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1957 SPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 1958 QLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 1959 PLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 1960 QLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 1961 PLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 1962 QLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 1963 PLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 1964 QLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 1965 PLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 1966 LGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 1967 LGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 1968 LGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 1969 LGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 1970 GDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 1971 GDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 1972 GDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 1973 GDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 1974 DRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 1975 DRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 1976 DRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 21977 DRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 1978 RLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 1979 RLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 1980 RLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 1981 RLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 1982 RLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 1983 RLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 1984 RLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 1985 RLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 1986 LNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 1987 LNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 1988 LNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 1989 LNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 1990 LNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 1991 LNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 1992 LNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 1993 LNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 1994 NVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 1995 NVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 1996 NVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 1997 NVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 1998 NVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 1999 NVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2000 NVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2001 NVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2002 VEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2003 VEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 2004 VEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 2005 VEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 2006 EVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 2007 VEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 2008 VEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 2009 VEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 2010 EVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2011 EVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2012 EVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2013 EVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2014 EVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2015 EVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2016 EVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2017 EVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2018 VDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2019 VDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2020 VDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2021 VDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2022 VDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2023 VDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2024 VDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2025 VDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2026 EVNTLRCQLGDRLNVEVDAAPTVD, SEQ ID NO: 2027 EVNTLRSQLGDRLNVEVDAAPTVD, SEQ ID NO: 2028 EVNTLRCPLGDRLNVEVDAAPTVD, SEQ ID NO: 2029 EVNTLRSPLGDRLNVEVDAAPTVD, SEQ ID NO: 2030 EVNTLRCQLGDRLNVEVDTAPTVD, SEQ ID NO: 2031 EVNTLRSQLGDRLNVEVDTAPTVD, SEQ ID NO: 2032 EVNTLRCPLGDRLNVEVDTAPTVD, SEQ ID NO: 2033 EVNTLRSPLGDRLNVEVDTAPTVD, SEQ ID NO: 2034 VNTLRCQLGDRLNVEVDAAPTVDL, SEQ ID NO: 2035 VNTLRSQLGDRLNVEVDAAPTVDL, SEQ ID NO: 2036 VNTLRCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 2037 VNTLRSPLGDRLNVEVDAAPTVDL, SEQ ID NO: 2038 VNTLRCQLGDRLNVEVDTAPTVDL, SEQ ID NO: 2039 VNTLRSQLGDRLNVEVDTAPTVDL, SEQ ID NO: 2040 VNTLRCPLGDRLNVEVDTAPTVDL, SEQ ID NO: 2041 VNTLRSPLGDRLNVEVDTAPTVDL, SEQ ID NO: 2042 NTLRCQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2043 NTLRSQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2044 NTLRCPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2045 NTLRSPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2046 NTLRCQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2047 NTLRSQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2048 NTLRCPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2049 NTLRSPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2050 TLRCQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2051 TLRSQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2052 TLRCPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2053 TLRSPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2054 TLRCQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2055 TLRSQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2056 TLRCPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2057 TLRSPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2058 TLRCQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2059 TLRSQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2060 TLRCPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2061 TLRSPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2062 TLRCQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2063 TLRSQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2064 TLRCPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2065 TLRSPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2066 LRCQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2067 LRSQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2068 LRCPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2069 LRSPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2070 LRCQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2071 LRSQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2072 LRCPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2073 LRSPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2074 LRCQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2075 LRSQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2076 LRCPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2077 LRSPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2078 LRCQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2079 LRSQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2080 LRCPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2081 LRSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2082 RCQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2083 RSQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2084 RCPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2085 RSPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2086 RCQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2087 RSQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2088 RCPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2089 RSPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2090 RCQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2091 RSQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2092 RCPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2093 RSPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2094 RCQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2095 RSQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2096 RCPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2097 RSPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2098 CQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2099 SQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2100 CPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2101 SPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2102 CQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2103 SQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2104 CPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2105 SPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2106 CQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2107 SQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2108 CPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2109 SPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2110 CQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2111 SQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2112 CPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2113 SPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2114 QLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2115 PLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2116 QLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2117 PLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2118 QLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2119 PLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2120 QLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2121 PLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2122 LGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2123 LGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2124 LGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2125 LGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2126 GDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2127 GDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2128 GDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2129 GDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2130 DRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2131 DRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2132 DRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2133 DRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2134 DRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2135 DRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2136 DRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2137 DRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2138 RLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2139 RLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2140 RLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2141 RLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2142 RLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2143 RLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2144 RLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2145 RLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2146 LNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2147 LNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2148 LNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2149 LNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2150 LNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2151 LNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2152 LNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2153 LNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2154 NVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2155 NVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 2156 NVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 2157 NVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 2158 NVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 2159 NVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 2160 NVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 2161 NVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 2162 VEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2163 VEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2164 VEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2165 VEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2166 VEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2167 VEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2168 VEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2169 VEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2170 EVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2171 EVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2172 EVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2173 EVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2174 EVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2175 EVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2176 EVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2177 EVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2178 EVNTLRCQLGDRLNVEVDAAPTVDL, SEQ ID NO: 2179 EVNTLRSQLGDRLNVEVDAAPTVDL, SEQ ID NO: 2180 EVNTLRCPLGDRLNVEVDAAPTVDL, SEQ ID NO: 2181 EVNTLRSPLGDRLNVEVDAAPTVDL, SEQ ID NO: 2182 EVNTLRCQLGDRLNVEVDTAPTVDL, SEQ ID NO: 2183 EVNTLRSQLGDRLNVEVDTAPTVDL, SEQ ID NO: 2184 EVNTLRCPLGDRLNVEVDTAPTVDL, SEQ ID NO: 2185 EVNTLRSPLGDRLNVEVDTAPTVDL, SEQ ID NO: 2186 VNTLRCQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2187 VNTLRSQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2188 VNTLRCPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2189 VNTLRSPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2190 VNTLRCQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2191 VNTLRSQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2192 VNTLRCPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2193 VNTLRSPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2194 NTLRCQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2195 NTLRSQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2196 NTLRCPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2197 NTLRSPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2198 NTLRCQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2199 NTLRSQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2200 NTLRCPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2201 NTLRSPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2202 NTLRCQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2203 NTLRSQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2204 NTLRCPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2205 NTLRSPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2206 NTLRCQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2207 NTLRSQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2208 NTLRCPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2209 NTLRSPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2210 TLRCQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2211 TLRSQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2212 TLRCPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2213 TLRSPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2214 TLRCQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2215 TLRSQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2216 TLRCPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2217 TLRSPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2218 TLRCQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2219 TLRSQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2220 TLRCPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2221 TLRSPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2222 TLRCQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2223 TLRSQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2224 TLRCPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2225 TLRSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2226 LRCQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2227 LRSQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2228 LRCPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2229 LRSPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2230 LRCQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2231 LRSQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2232 LRCPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2233 LRSPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2234 LRCQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2235 LRSQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2236 LRCPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2237 LRSPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2238 LRCQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2239 LRSQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2240 LRCPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2241 LRSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2242 RCQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2243 RSQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2244 RCPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2245 RSPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2246 RCQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2247 RSQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2248 RCPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2249 RSPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2250 RCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2251 RSQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2252 RCPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2253 RSPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2254 RCQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2255 RSQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2256 RCPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2257 RSPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2258 CQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2259 SQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2260 CPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2261 SPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2262 CQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2263 SQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2264 CPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2265 SPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2266 CQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2267 SQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2268 CPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2269 SPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2274 CQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2271 SQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2272 CPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2273 SPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2274 QLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2275 PLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2276 QLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2277 PLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2278 QLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2279 PLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2280 QLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2281 PLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2282 LGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2283 LGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2284 LGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 42285 LGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2286 GDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2287 GDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2288 GDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2289 GDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2290 GDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2291 GDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2292 GDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2293 GDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2294 DRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2295 DRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2296 DRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2297 DRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2298 DRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2299 DRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2300 DRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2301 DRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2302 RLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2303 RLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2304 RLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2305 RLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2306 RLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2307 RLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2308 RLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2309 RLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2310 LNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2311 LNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 2312 LNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 2313 LNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 2314 LNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 2315 LNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 2316 LNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 2317 LNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 2318 NVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2319 NVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2320 NVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2321 NVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2322 NVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2323 NVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2324 NVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2325 NVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2326 VEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2327 VEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2328 VEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2329 VEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2330 VEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2331 VEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2332 VEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2333 VEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2334 EVNTLRCQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2335 EVNTLRSQLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2336 EVNTLRCPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2337 EVNTLRSPLGDRLNVEVDAAPTVDLN, SEQ ID NO: 2338 EVNTLRCQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2339 EVNTLRSQLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2340 EVNTLRCPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2341 EVNTLRSPLGDRLNVEVDTAPTVDLN, SEQ ID NO: 2342 VNTLRCQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2343 VNTLRSQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2344 VNTLRCPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2345 VNTLRSPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2346 VNTLRCQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2347 VNTLRSQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2348 VNTLRCPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2349 VNTLRSPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2350 VNTLRCQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2351 VNTLRSQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2352 VNTLRCPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2353 VNTLRSPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2354 VNTLRCQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2355 VNTLRSQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2356 VNTLRCPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2357 VNTLRSPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2358 NTLRCQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2359 NTLRSQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2360 NTLRCPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2361 NTLRSPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2362 NTLRCQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2363 NTLRSQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2364 NTLRCPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2365 NTLRSPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2366 NTLRCQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2367 NTLRSQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2368 NTLRCPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2369 NTLRSPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2370 NTLRCQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2371 NTLRSQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2372 NTLRCPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2373 NTLRSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2374 TLRCQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2375 TLRSQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2376 TLRCPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2377 TLRSPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2378 TLRCQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2379 TLRSQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2380 TLRCPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2381 TLRSPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2382 TLRCQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2383 TLRSQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2384 TLRCPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2385 TLRSPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2386 TLRCQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2387 TLRSQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2388 TLRCPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2389 TLRSPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2390 LRCQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2391 LRSQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2392 LRCPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2393 LRSPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2394 LRCQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2395 LRSQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2396 LRCPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2397 LRSPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2398 LRCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2399 LRSQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2400 LRCPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2401 LRSPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2402 LRCQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2403 LRSQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2404 LRCPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2405 LRSPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2406 RCQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2407 RSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2408 RCPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2409 RSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2410 RCQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2411 RSQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2412 RCPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2413 RSPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2414 RCQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2415 RSQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2416 RCPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2417 RSPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2418 RCQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2419 RSQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2420 RCPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2421 RSPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2422 CQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2423 SQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2424 CPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2425 SPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2426 CQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2427 SQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2428 CPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2429 SPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2430 CQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2431 SQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2432 CPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2433 SPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2434 CQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2435 SQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2436 CPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2437 SPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2438 QLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2439 PLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2440 QLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2441 PLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2442 QLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2443 PLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2444 QLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2445 PLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2446 LGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2447 LGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2448 LGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2449 LGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2450 LGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2451 LGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2452 LGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2453 LGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2454 GDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2455 GDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2456 GDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2457 GDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2458 GDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2459 GDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2460 GDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2461 GDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2462 DRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2463 DRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2464 DRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2465 DRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2466 DRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2467 DRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2468 DRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2469 DRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2470 RLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2471 RLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 2472 RLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 2473 RLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 2474 RLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 2475 RLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 2476 RLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 2477 RLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 2478 LNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2479 LNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2480 LNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2481 LNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2482 LNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2483 LNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2484 LNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2485 LNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2486 NVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2487 NVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2488 NVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2489 NVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2490 NVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2491 NVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2492 NVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2493 NVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2494 EVNTLRCQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2495 EVNTLRSQLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2496 EVNTLRCPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2497 EVNTLRSPLGDRLNVEVDAAPTVDLNQ, SEQ ID NO: 2498 EVNTLRCQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2499 EVNTLRSQLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2500 EVNTLRCPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2501 EVNTLRSPLGDRLNVEVDTAPTVDLNQ, SEQ ID NO: 2502 EVNTLRCQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2503 EVNTLRSQLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2504 EVNTLRCPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2505 EVNTLRSPLGDRLNVEVDAAPTVDLNR, SEQ ID NO: 2506 EVNTLRCQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2507 EVNTLRSQLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2508 EVNTLRCPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2509 EVNTLRSPLGDRLNVEVDTAPTVDLNR, SEQ ID NO: 2510 VNTLRCQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2511 VNTLRSQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2512 VNTLRCPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2513 VNTLRSPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2514 VNTLRCQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2515 VNTLRSQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2516 VNTLRCPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2517 VNTLRSPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2518 VNTLRCQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2519 VNTLRSQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2520 VNTLRCPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2521 VNTLRSPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2522 VNTLRCQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2523 VNTLRSQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2524 VNTLRCPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2525 VNTLRSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2526 NTLRCQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2527 NTLRSQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2528 NTLRCPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2529 NTLRSPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2530 NTLRCQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2531 NTLRSQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2532 NTLRCPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2533 NTLRSPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2534 NTLRCQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2535 NTLRSQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2536 NTLRCPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2537 NTLRSPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2538 NTLRCQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2539 NTLRSQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2540 NTLRCPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2541 NTLRSPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2542 TLRCQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2543 TLRSQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2544 TLRCPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2545 TLRSPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2546 TLRCQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2547 TLRSQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2548 TLRCPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2549 TLRSPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2550 TLRCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2551 TLRSQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2552 TLRCPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2553 TLRSPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2554 TLRCQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2555 TLRSQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2556 TLRCPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2557 TLRSPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2558 LRCQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2559 LRSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2560 LRCPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2561 LRSPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2562 LRCQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2563 LRSQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2564 LRCPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2565 LRSPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2566 LRCQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2567 LRSQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2568 LRCPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2569 LRSPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2570 LRCQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2571 LRSQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2572 LRCPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2573 LRSPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2574 RCQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2575 RSQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2576 RCPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2577 RSPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2578 RCQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2579 RSQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2580 RCPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2581 RSPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2582 RCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2583 RSQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2584 RCPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2585 RSPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2586 RCQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2587 RSQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2588 RCPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2589 RSPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2590 CQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2591 SQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2592 CPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2593 SPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2594 CQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2595 SQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2596 CPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2597 SPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2598 CQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2599 SQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2600 CPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2601 SPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2602 CQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2603 SQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2604 CPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2605 SPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2606 QLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2607 PLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2608 QLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2609 PLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2610 QLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2611 PLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2612 QLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2613 PLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2614 QLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2615 PLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2616 QLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2617 PLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2618 QLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2619 PLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2620 QLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2621 PLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2622 LGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2623 LGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2624 LGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2625 LGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2626 LGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2627 LGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2628 LGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2629 LGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2630 GDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2631 GDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2632 GDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2633 GDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2634 GDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2635 GDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2636 GDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2637 GDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2638 DRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2639 DRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 2640 DRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 2641 DRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 2642 DRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 2643 DRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 2644 DRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 2645 DRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 2646 RLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2647 RLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2648 RLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2649 RLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2650 RLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2651 RLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2652 RLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2653 RLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2654 LNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2655 LNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2656 LNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2657 LNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2658 LNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2659 LNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2660 LNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2661 LNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2662 EVNTLRCQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2663 EVNTLRSQLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2664 EVNTLRCPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2665 EVNTLRSPLGDRLNVEVDAAPTVDLNQV, SEQ ID NO: 2666 EVNTLRCQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2667 EVNTLRSQLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2668 EVNTLRCPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2669 EVNTLRSPLGDRLNVEVDTAPTVDLNQV, SEQ ID NO: 2670 EVNTLRCQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2671 EVNTLRSQLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2672 EVNTLRCPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2673 EVNTLRSPLGDRLNVEVDAAPTVDLNRV, SEQ ID NO: 2674 EVNTLRCQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2675 EVNTLRSQLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2676 EVNTLRCPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2677 EVNTLRSPLGDRLNVEVDTAPTVDLNRV, SEQ ID NO: 2678 VNTLRCQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2679 VNTLRSQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2680 VNTLRCPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2681 VNTLRSPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2682 VNTLRCQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2683 VNTLRSQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2684 VNTLRCPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2685 VNTLRSPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2686 VNTLRCQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2687 VNTLRSQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2688 VNTLRCPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2689 VNTLRSPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2690 VNTLRCQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2691 VNTLRSQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2692 VNTLRCPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2693 VNTLRSPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2694 NTLRCQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2695 NTLRSQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2696 NTLRCPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2697 NTLRSPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2698 NTLRCQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2699 NTLRSQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2700 NTLRCPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2701 NTLRSPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2702 NTLRCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2703 NTLRSQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2704 NTLRCPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2705 NTLRSPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2706 NTLRCQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2707 NTLRSQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2708 NTLRCPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2709 NTLRSPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2710 TLRCQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2711 TLRSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2712 TLRCPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2713 TLRSPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2714 TLRCQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2715 TLRSQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2716 TLRCPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2717 TLRSPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2718 TLRCQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2719 TLRSQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2720 TLRCPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2721 TLRSPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2722 TLRCQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2723 TLRSQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2724 TLRCPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2725 TLRSPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2726 LRCQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2727 LRSQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2728 LRCPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2729 LRSPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2730 LRCQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2731 LRSQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2732 LRCPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2733 LRSPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2734 LRCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2735 LRSQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2736 LRCPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2737 LRSPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2738 LRCQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2739 LRSQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2740 LRCPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2741 LRSPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2742 RCQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2743 RSQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2744 RCPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2745 RSPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2746 RCQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2747 RSQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2748 RCPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2749 RSPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2750 RCQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2751 RSQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2752 RCPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2753 RSPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2754 RCQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2755 RSQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2756 RCPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2757 RSPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2758 CQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2759 SQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2760 CPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2761 SPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2762 CQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2763 SQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2764 CPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2765 SPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2766 CQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2767 SQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2768 CPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2769 SPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2770 CQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2771 SQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2772 CPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2773 SPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2774 CQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2775 SQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2776 CPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2777 SPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2778 CQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2779 SQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2780 CPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2781 SPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2782 CQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2783 SQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2784 CPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2785 SPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2786 CQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2787 SQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2788 CPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2789 SPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2790 QLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2791 PLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2792 QLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2793 PLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2794 QLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2795 PLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2796 QLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2797 PLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2798 QLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2799 PLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2800 QLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2801 PLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2802 QLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2803 PLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2804 QLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2805 PLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2806 LGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2807 LGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2808 LGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2809 LGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2810 LGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2811 LGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2812 LGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2813 LGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2814 GDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2815 GDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 2816 GDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 2817 GDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 2818 GDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 2819 GDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 2820 GDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 2821 GDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 2822 DRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2823 DRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 2824 DRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2825 DRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 2826 DRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2827 DRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 2828 DRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2829 DRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 2830 RLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2831 RLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 2832 RLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2833 RLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 2834 RLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2835 RLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 2836 RLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2837 RLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 2838 EVNTLRCQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2839 EVNTLRSQLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2840 EVNTLRCPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2841 EVNTLRSPLGDRLNVEVDAAPTVDLNQVL, SEQ ID NO: 2842 EVNTLRCQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2843 EVNTLRSQLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2844 EVNTLRCPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2845 EVNTLRSPLGDRLNVEVDTAPTVDLNQVL, SEQ ID NO: 2846 EVNTLRCQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2847 EVNTLRSQLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2848 EVNTLRCPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2849 EVNTLRSPLGDRLNVEVDAAPTVDLNRVL, SEQ ID NO: 2850 EVNTLRCQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2851 EVNTLRSQLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2852 EVNTLRCPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2853 EVNTLRSPLGDRLNVEVDTAPTVDLNRVL, SEQ ID NO: 2854 VNTLRCQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2855 VNTLRSQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2856 VNTLRCPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2857 VNTLRSPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 2858 VNTLRCQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2859 VNTLRSQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2860 VNTLRCPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2861 VNTLRSPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 2862 VNTLRCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2863 VNTLRSQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2864 VNTLRCPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2865 VNTLRSPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 2866 VNTLRCQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2867 VNTLRSQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2868 VNTLRCPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2869 VNTLRSPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 2870 NTLRCQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2871 NTLRSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2872 NTLRCPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2873 NTLRSPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 2874 NTLRCQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2875 NTLRSQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2876 NTLRCPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2877 NTLRSPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 2878 NTLRCQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2879 NTLRSQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2880 NTLRCPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2881 NTLRSPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 2882 NTLRCQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2883 NTLRSQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2884 NTLRCPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2885 NTLRSPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 2886 TLRCQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2887 TLRSQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2888 TLRCPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2889 TLRSPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 2890 TLRCQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2891 TLRSQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2892 TLRCPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2893 TLRSPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 2894 TLRCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2895 TLRCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2896 TLRCPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2897 TLRSPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 2898 TLRCQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2899 TLRSQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2900 TLRCPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2901 TLRSPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 2902 LRCQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2903 LRSQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2904 LRCPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2905 LRSPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 2906 LRCQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2907 LRSQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2908 LRCPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2909 LRSPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 2910 LRCQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2911 LRSQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2912 LRCPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2913 LRSPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 2914 LRCQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2915 LRSQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2916 LRCPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2917 LRSPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 2918 RCQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2919 RSQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2920 RCPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2921 RSPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 2922 RCQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2923 RSQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2924 RCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2925 RSPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 2926 RCQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2927 RSQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2928 RCPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2929 RSPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 2930 RCQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2931 RSQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2932 RCPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2933 RSPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 2934 RCQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2935 RSQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2936 RCPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2937 RSPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 2938 RCQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2939 RSQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2940 RCPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2941 RSPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 2942 RCQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2943 RSQLGDRLNVEVDAAPTVDLNRVLNETRN SEQ ID NO: 2944 RCPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2945 RSPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 2946 RCQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2947 RSQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2948 RCPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2949 RSPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 2950 CQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2951 SQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2952 CPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2953 SPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 2954 CQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2955 SQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2956 CPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2957 SPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 2958 CQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2959 SQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2960 CPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2961 SPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 2962 CQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2963 SQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2964 CPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2965 SPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 2966 CQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2967 SQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2968 CPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2969 SPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 2970 CQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2971 SQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2972 CPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2973 SPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 2974 CQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2975 SQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2976 CPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2977 SPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 2978 CQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2979 SQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2980 CPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2981 SPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 2982 QLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2983 PLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 2984 QLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2985 PLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 2986 QLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2987 PLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 2988 QLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2989 PLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 2990 QLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2991 PLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 2992 QLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2993 PLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 2994 QLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2995 PLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 2996 QLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2997 PLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 2998 LGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 2999 LGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3000 LGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3001 LGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3002 LGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3003 LGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3004 LGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3005 LGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3006 GDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3007 GDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3008 GDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3009 GDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3010 GDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3011 GDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3012 GDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3013 GDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3014 DRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3015 DRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3016 DRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3017 DRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3018 DRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3019 DRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3020 DRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3021 DRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3022 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 3023 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 3024 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 3025 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLN, SEQ ID NO: 3026 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 3027 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 3028 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 3029 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLN, SEQ ID NO: 3030 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 3031 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 3032 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 3033 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLN, SEQ ID NO: 3034 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 3035 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 3036 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 3037 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLN, SEQ ID NO: 3038 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3039 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3040 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3041 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3042 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3043 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3044 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3045 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3046 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3047 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3048 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3049 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3050 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3051 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3052 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3053 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3054 NTLRCQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3055 NTLRSQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3056 NTLRCPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3057 NTLRSPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3058 NTLRCQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3059 NTLRSQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3060 NTLRCPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3061 NTLRSPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3062 NTLRCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3063 NTLRSQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3064 NTLRCPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3065 NTLRSPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3066 NTLRCQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3067 NTLRSQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3068 NTLRCPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3069 NTLRSPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3070 TLRCQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3071 TLRSQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3072 TLRCPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3073 TLRSPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3074 TLRCQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3075 TLRSQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3076 TLRCPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3077 TLRSPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3078 TLRCQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3079 TLRSQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3080 TLRCPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3081 TLRSPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3082 TLRCQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3083 TLRSQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3084 TLRCPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3085 TLRSPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3086 LRCQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3087 LRSQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3088 LRCPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3089 LRSPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3090 LRCQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3091 LRSQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3092 LRCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3093 LRSPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3094 LRCQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3095 LRSQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3096 LRCPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3097 LRSPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3098 LRCQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3099 LRSQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3100 LRCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3101 LRSPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3102 LRCQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3103 LRSQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3104 LRCPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3105 LRSPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3106 LRCQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3107 LRSQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3108 LRCPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3109 LRSPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3110 LRCQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3111 LRSQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3112 LRCPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3113 LRSPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3114 LRCQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3115 LRSQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3116 LRCPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3117 LRSPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3118 RCQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3119 RSQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3120 RCPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3121 RSPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3122 RCQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3123 RSQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3124 RCPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3125 RSPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3126 RCQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3127 RSQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3128 RCPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3129 RSPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3130 RCQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3131 RSQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3132 RCPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3133 RSPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3134 RCQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3135 RSQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3136 RCPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3137 RSPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3138 RCQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3139 RSQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3140 RCPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3141 RSPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3142 RCQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3143 RSQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3144 RCPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3145 RSPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3146 RCQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3147 RSQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3148 RCPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3149 RSPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3150 CQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3151 SQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3152 CPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3153 SPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3154 CQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3155 SQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3156 CPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3157 SPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3158 CQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3159 SQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3160 CPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3161 SPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3162 CQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3163 SQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3164 CPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3165 SPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3166 CQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3167 SQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3168 CPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3169 SPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3170 CQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3171 SQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3172 CPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3173 SPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3174 CQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3175 SQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3176 CPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3177 SPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3178 CQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3179 SQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3180 CPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3181 SPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3182 QLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3183 PLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3184 QLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3185 PLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3186 QLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3187 PLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3188 QLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3189 PLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3190 QLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3191 PLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3192 QLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3193 PLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3194 QLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3195 PLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3196 QLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3197 PLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3198 LGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3199 LGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3200 LGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3201 LGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3202 LGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3203 LGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3204 LGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3205 LGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3206 GDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3207 GDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3208 GDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3209 GDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3210 GDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3211 GDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3212 GDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3213 GDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3214 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3215 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3216 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3217 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNE, SEQ ID NO: 3218 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3219 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3220 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3221 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNE, SEQ ID NO: 3222 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3223 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3224 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3225 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNE, SEQ ID NO: 3226 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3227 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3228 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3229 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNE, SEQ ID NO: 3230 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3231 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3232 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3233 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3234 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3235 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3236 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3237 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3238 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3239 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3240 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3241 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3242 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3243 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3244 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3245 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3246 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3247 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3248 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3249 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3250 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3251 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3252 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3253 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3254 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3255 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3256 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3257 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3258 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3259 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3260 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3261 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3262 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3263 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3264 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3265 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3266 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3267 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3268 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3269 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3270 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3271 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3272 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3273 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3274 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3275 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3276 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3277 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3278 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3279 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3280 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3281 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3282 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3283 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3284 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3285 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3286 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3287 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3288 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3289 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3290 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3291 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3292 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3293 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3294 LRCQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3295 LRSQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3296 LRCPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3297 LRSPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3298 LRCQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3299 LRSQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3300 LRCPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3301 LRSPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3302 LRCQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3303 LRSQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3304 LRCPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3305 LRSPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3306 LRCQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3307 LRSQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3308 LRCPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3309 LRSPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3310 LRCQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3311 LRSQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3312 LRCPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3313 LRSPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3314 LRCQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3315 LRSQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3316 LRCPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3317 LRSPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3318 LRCQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3319 LRSQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3320 LRCPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3321 LRSPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3322 LRCQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3323 LRSQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3324 LRCPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3325 LRSPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3326 RCQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3327 RSQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3328 RCPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3329 RSPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3330 RCQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3331 RSQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3332 RCPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3333 RSPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3334 RCQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3335 RSQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3336 RCPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3337 RSPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3338 RCQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3339 RSQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3340 RCPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3341 RSPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3342 RCQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3343 RSQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3344 RCPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3345 RSPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3346 RCQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3347 RSQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3348 RCPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3349 RSPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3350 RCQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3351 RSQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3352 RCPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3353 RSPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3354 RCQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3355 RSQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3356 RCPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3357 RSPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3358 CQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3359 SQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3360 CPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3361 SPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3362 CQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3363 SQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3364 CPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3365 SPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3366 CQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3367 SQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3368 CPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3369 SPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3370 CQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3371 SQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3372 CPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3373 SPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3374 CQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3375 SQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3376 CPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3377 SPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3378 CQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3379 SQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3380 CPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3381 SPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3382 CQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3383 SQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3384 CPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3385 SPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3386 CQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3387 SQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3388 CPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3389 SPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3390 QLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3391 PLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3392 QLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3393 PLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3394 QLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3395 PLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3396 QLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3397 PLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3398 QLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3399 PLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3400 QLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3401 PLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3402 QLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3403 PLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3404 QLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3405 PLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3406 LGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3407 LGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3408 LGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3409 LGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3410 LGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3411 LGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3412 ELGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3413 LGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3414 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3415 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3416 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3417 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNET, SEQ ID NO: 3418 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3419 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3420 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3421 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNET, SEQ ID NO: 3422 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3423 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3424 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3425 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNET, SEQ ID NO: 3426 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3427 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3428 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3429 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNET, SEQ ID NO: 3430 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3431 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3432 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3433 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3434 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3435 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3436 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3437 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3438 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3439 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3440 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3441 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3442 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3443 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3444 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3445 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3446 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3447 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3448 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3449 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3450 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3451 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3452 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3453 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3454 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3455 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3456 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3457 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3458 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3459 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3460 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3461 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3462 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3463 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3464 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3465 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3466 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3467 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3468 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3469 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3470 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3471 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3472 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3473 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3474 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3475 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3476 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3477 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3478 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3479 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3480 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3481 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3482 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3483 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3484 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3485 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3486 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3487 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3488 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3489 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3490 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3491 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3492 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3493 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3494 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3495 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3496 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3497 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3498 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3499 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3500 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3501 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3502 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3503 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3504 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3505 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3506 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3507 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3508 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3509 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3510 LRCQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3511 LRSQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3512 LRCPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3513 LRSPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3514 LRCQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3515 LRSQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3516 LRCPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3517 LRSPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3518 LRCQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3519 LRSQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3520 LRCPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3521 LRSPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3522 LRCQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3523 LRSQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3524 LRCPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3525 LRSPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3526 LRCQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3527 LRSQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3528 LRCPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3529 LRSPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3530 LRCQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3531 LRSQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3532 LRCPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3533 LRSPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3534 LRCQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3535 LRSQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3536 LRCPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3537 LRSPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3538 LRCQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3539 LRSQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3540 LRCPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3541 LRSPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3542 RCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3543 RSQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3544 RCPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3545 RSPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3546 RCQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3547 RSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3548 RCPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3549 RSPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3550 RCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3551 RSQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3552 RCPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3553 RSPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3554 RCQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3555 RSQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3556 RCPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3557 RSPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3558 RCQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3559 RSQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3560 RCPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3561 RSPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3562 RCQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3563 RSQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3564 RCPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3565 RSPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3566 RCQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3567 RSQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3568 RCPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3569 RSPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3570 RCQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3571 RSQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3572 RCPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3573 RSPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3574 CQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3575 SQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3576 CPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3577 SPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3578 CQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3579 SQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3580 CPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3581 SPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3582 CQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3583 SQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3584 CPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3585 SPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3586 CQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3587 SQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3588 CPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3589 SPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3590 CQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3591 SQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3592 CPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3593 SPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3594 CQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3595 SQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3596 CPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3597 SPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3598 CQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3599 SQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3600 CPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3601 SPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3602 CQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3603 SQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3604 CPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3605 SPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3606 QLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3607 PLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3608 QLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3609 PLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3610 QLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3611 PLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3612 QLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3613 PLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3614 QLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3615 PLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3616 QLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3617 PLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3618 QLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3619 PLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3620 QLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3621 PLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3622 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3623 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3624 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3625 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETR, SEQ ID NO: 3626 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3627 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3628 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3629 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETR, SEQ ID NO: 3630 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3631 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3632 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3633 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETR, SEQ ID NO: 3634 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3635 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3636 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3637 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETR, SEQ ID NO: 3638 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3639 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3640 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3641 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3642 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3643 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3644 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3645 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3646 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3647 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3648 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3649 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3650 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3651 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3652 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3653 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3654 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3655 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3656 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3657 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3658 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3659 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3660 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3661 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3662 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3663 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3664 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3665 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3666 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3667 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3668 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3669 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3670 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3671 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3672 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3673 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3674 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3675 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3676 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3677 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3678 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3679 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3680 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3681 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3682 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3683 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3684 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3685 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3686 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3687 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3688 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3689 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3690 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3691 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3692 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3693 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3694 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3695 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3696 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3697 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3698 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3699 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3700 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3701 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3702 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3703 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3704 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3705 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3706 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3707 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3708 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3709 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3710 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3711 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3712 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3713 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3714 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3715 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3716 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3717 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3718 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3719 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3720 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3721 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3722 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3723 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3724 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3725 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3726 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3727 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3728 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3729 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3730 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3731 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3732 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3733 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3734 LRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3735 LRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3736 LRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3737 LRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3738 LRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3739 LRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3740 LRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3741 LRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3742 LRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3743 LRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3744 LRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3745 LRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3746 LRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3747 LRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3748 LRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3749 LRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3750 LRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3751 LRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3752 LRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3753 LRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3754 LRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3755 LRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3756 LRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3757 LRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3758 LRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3759 LRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3760 LRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3761 LRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3762 LRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3763 LRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3764 LRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3765 LRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3766 RCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3767 RSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3768 RCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3769 RSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3770 RCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3771 RSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3772 RCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3773 RSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3774 RCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3775 RSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3776 RCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3777 RSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3778 RCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3779 RSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3780 RCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3781 RSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3782 RCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3783 RSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3784 RCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3785 RSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3786 RCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3787 RSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3788 RCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3789 RSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3790 RCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3791 RSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3792 RCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3793 RSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3794 RCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3795 RSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3796 RCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3797 RSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3798 CQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3799 SQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3800 CPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3801 SPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3802 CQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3803 SQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3804 CPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3805 SPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3806 CQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3807 SQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3808 CPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3809 SPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3810 CQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3811 SQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3812 CPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3813 SPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3814 CQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3815 SQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3816 CPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3817 SPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3818 CQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3819 SQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3820 CPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3821 SPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 3822 CQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3823 SQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3824 CPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3825 SPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3826 CQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3827 SQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3828 CPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3829 SPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 3830 E VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3831 E VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3832 E VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3833 E VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRS, SEQ ID NO: 3834 E VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3835 E VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3836 E VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3837 E VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRS, SEQ ID NO: 3838 E VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3839 E VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3840 E VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3841 E VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRS, SEQ ID NO: 3842 E VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3843 E VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3844 E VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3845 E VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRS, SEQ ID NO: 3846 E VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3847 E VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3848 E VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3849 E VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRN, SEQ ID NO: 3850 E VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3851 E VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3852 E VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3853 E VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRN, SEQ ID NO: 3854 E VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3855 E VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3856 E VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3857 E VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRN, SEQ ID NO: 3858 E VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3859 E VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3860 E VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3861 E VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRN, SEQ ID NO: 3862 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3863 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3864 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3865 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 3866 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3867 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3868 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3869 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 3870 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3871 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3872 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3873 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 3874 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3875 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3876 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3877 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 3878 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3879 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3880 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3881 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 3882 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3883 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3884 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3885 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 3886 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3887 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3888 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3889 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 3890 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3891 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3892 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3893 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 3894 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3895 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3896 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3897 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 3898 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3899 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3900 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3901 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 3902 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3903 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3904 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3905 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 3906 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3907 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3908 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3909 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 3910 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3911 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3912 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3913 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 3914 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3915 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3916 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3917 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 3918 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3919 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3920 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3921 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 3922 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3923 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3924 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3925 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 3926 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3927 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3928 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3929 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 3930 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3931 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3932 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3933 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 3934 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3935 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3936 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3937 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 3938 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3939 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3940 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3941 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 3942 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3943 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3944 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3945 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 3946 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3947 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3948 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3949 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 3950 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3951 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3952 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3953 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 3954 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3955 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3956 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3957 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 3958 LRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3959 LRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3960 LRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3961 LRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3962 LRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3963 LRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3964 LRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3965 LRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 3966 LRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3967 LRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3968 LRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3969 LRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3970 LRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3971 LRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3972 LRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3973 LRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 3974 LRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3975 LRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3976 LRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3977 LRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3978 LRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3979 LRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3980 LRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3981 LRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 3982 LRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3983 LRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3984 LRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3985 LRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3986 LRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3987 LRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3988 LRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3989 LRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 3990 RCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3991 RSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3992 RCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3993 RSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3994 RCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3995 RSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3996 RCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3997 RSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 3998 RCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 3999 RSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4000 RCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4001 RSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4002 RCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4003 RSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4004 RCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4005 RSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4006 RCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4007 RSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4008 RCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4009 RSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4010 RCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4011 RSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4012 RCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4013 RSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4014 RCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4015 RSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4016 RCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4017 RSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4018 RCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4019 RSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4020 RCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4021 RSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4022 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 4023 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 4024 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 4025 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQ, SEQ ID NO: 4026 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 4027 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 4028 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 4029 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQ, SEQ ID NO: 4030 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 4031 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 4032 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 4033 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQ, SEQ ID NO: 4034 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 4035 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 4036 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 4037 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQ, SEQ ID NO: 4038 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 4039 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 4040 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 4041 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQ, SEQ ID NO: 4042 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 4043 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 4044 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 4045 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQ, SEQ ID NO: 4046 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 4047 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 4048 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 4049 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQ, SEQ ID NO: 4050 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 4051 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 4052 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 4053 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQ, SEQ ID NO: 4054 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4055 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4056 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4057 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4058 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4059 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4060 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4061 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4062 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4063 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4064 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4065 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4066 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4067 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4068 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4069 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4070 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4071 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4072 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4073 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4074 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4075 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4076 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4077 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4078 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4079 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4080 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4081 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4082 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4083 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4084 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4085 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4086 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4087 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4088 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4089 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4090 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4091 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4092 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4093 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4094 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4095 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4096 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4097 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4098 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4099 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4100 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4101 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4102 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4103 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4104 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4105 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4106 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4107 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4108 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4109 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4110 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4111 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4112 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4113 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4114 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4115 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4116 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4117 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4118 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4119 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4120 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4121 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4122 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4123 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4124 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4125 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4126 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4127 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4128 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4129 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4130 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4131 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4132 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4133 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4134 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4135 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4136 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4137 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4138 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4139 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4140 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4141 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4142 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4143 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4144 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4145 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4146 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4147 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4148 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4149 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4150 LRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4151 LRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4152 LRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4153 LRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4154 LRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4155 LRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4156 LRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4157 LRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4158 LRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4159 LRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4160 LRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4161 LRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4162 LRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4163 LRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4164 LRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4165 LRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4166 LRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4167 LRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4168 LRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4169 LRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4170 LRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4171 LRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4172 LRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4173 LRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4174 LRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4175 LRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4176 LRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4177 LRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4178 LRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4179 LRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4180 LRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4181 LRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4182 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4183 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4184 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4185 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQY, SEQ ID NO: 4186 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4187 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4188 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4189 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQY, SEQ ID NO: 4190 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4191 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4192 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4193 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQY, SEQ ID NO: 4194 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4195 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4196 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4197 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQY, SEQ ID NO: 4198 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4199 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4200 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4201 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQY, SEQ ID NO: 4202 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4203 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4204 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4205 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQY, SEQ ID NO: 4206 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4207 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4208 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4209 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQY, SEQ ID NO: 4210 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4211 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4212 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4213 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQY, SEQ ID NO: 4214 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4215 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4216 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4217 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4218 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4219 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4220 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4221 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4222 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4223 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4224 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4225 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4226 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4227 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4228 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4229 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4230 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4231 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4232 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4233 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4234 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4235 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4236 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4237 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4238 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4239 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4240 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4241 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4242 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4243 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4244 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4245 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4246 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4247 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4248 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4249 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4250 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4251 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4252 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4253 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4254 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4255 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4256 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4257 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4258 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4259 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4260 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4261 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4262 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4263 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4264 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4265 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4266 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4267 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4268 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4269 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4270 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4271 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4272 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4273 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4274 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4275 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4276 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4277 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4278 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4279 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4280 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4281 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4282 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4283 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4284 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4285 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4286 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4287 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4288 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4289 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4290 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4291 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4292 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4293 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4294 TLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4295 TLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4296 TLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4297 TLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4298 TLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4299 TLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4300 TLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4301 TLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4302 TLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4303 TLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4304 TLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4305 TLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4306 TLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4307 TLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4308 TLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4309 TLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4310 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4311 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4312 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4313 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYE, SEQ ID NO: 4314 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4315 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4316 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4317 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYE, SEQ ID NO: 4318 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4319 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4320 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4321 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYE, SEQ ID NO: 4322 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4323 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4324 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4325 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYE, SEQ ID NO: 4326 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4327 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4328 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4329 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYE, SEQ ID NO: 4330 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4331 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4332 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4333 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYE, SEQ ID NO: 4334 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4335 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4336 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4337 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYE, SEQ ID NO: 4338 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4339 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4340 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4341 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYE, SEQ ID NO: 4342 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4343 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4344 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4345 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4346 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4347 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4348 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4349 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4350 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4351 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4352 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4353 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4354 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4355 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4356 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 64357 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4358 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4359 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4360 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4361 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4362 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4363 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4364 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4365 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4366 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4367 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4368 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4369 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4370 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4371 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4372 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4373 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4374 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4375 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4376 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4377 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4378 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4379 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4380 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4381 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4382 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4383 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4384 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4385 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4386 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4387 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4388 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4389 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4390 NTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4391 NTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4392 NTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4393 NTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4394 NTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4395 NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4396 NTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4397 NTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4398 NTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4399 NTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4400 NTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4401 NTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4402 NTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4403 NTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4404 NTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4405 NTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4406 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4407 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4408 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4409 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4410 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4411 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4412 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4413 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEA, SEQ ID NO: 4414 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4415 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4416 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4417 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4418 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4419 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4420 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4421 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEA, SEQ ID NO: 4422 EVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4423 EVNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4424 EVNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4425 EVNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4426 EVNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4427 EVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4428 EVNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4429 EVNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEA, SEQ ID NO: 4430 EVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4431 EVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4432 EVNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4433 EVNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4434 EVNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4435 EVNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4436 EVNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4437 EVNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEA, SEQ ID NO: 4438 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4439 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4440 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4441 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4442 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4443 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4444 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4445 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRSQYEAL, SEQ ID NO: 4446 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4447 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4448 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4449 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4450 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4451 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4452 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4453 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRSQYEAL, SEQ ID NO: 4454 VNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4455 VNTLRSQLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4456 VNTLRCPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4457 VNTLRSPLGDRLNVEVDAAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4458 VNTLRCQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4459 VNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4460 VNTLRCPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4461 VNTLRSPLGDRLNVEVDTAPTVDLNQVLNETRNQYEAL, SEQ ID NO: 4462 VNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4463 VNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4464 VNTLRCPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4465 VNTLRSPLGDRLNVEVDAAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4466 VNTLRCQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4467 VNTLRSQLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4468 VNTLRCPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL, SEQ ID NO: 4469 VNTLRSPLGDRLNVEVDTAPTVDLNRVLNETRNQYEAL,

As is well known in the art, the use of the designation (C/S) means the amino acid at that position may be either C or S, (Q/P) means the amino acid at that position may be either Q or P, (A/T) means the amino acid at that position may be either A or T, (Q/R) means the amino acid at that position may be either Q or R and (S/N) means the amino acid at that position may be either S or N. It is also understood that the terms C-terminus or carboxy terminus are used interchangeably and are used herein as they are normally used in the art. An amino acid is composed of a carbon atom known as the a-carbon to which is attached a a-carboxylic acid, an a-amine and a side chain. In the peptide bond polymerization, the a-amino group from one amino acid binds to the a-carboxylic acid group of an adjacent amino acid in the peptide polymer. The polymer thus includes a free a-carboxylic acid on one end (the C-terminus) and a free a-amine group on the opposite end (the N-terminus or amino terminus). Any of the peptides disclosed herein may be modified to increase the stability and activity of the compositions as is well known in the art. Such modifications would include, but is not limited to bonding of acetyl or amide groups to the appropriate ends of the peptides.

It is also understood that one of skill in the art would understand that the peptides are disclosed using the one letter amino acid abbreviations as follows:

A=Ala=alanine R=Arg=arginine N=Asp=asparagine D=Asp=aspartic acid C=Cys=cysteine E=Glu=glutamic acid Q=Gln=glutamine G=Gly=glycine H=His=histidine I=Ile=isoleucine L=Leu=leucine K=Lys=lysine M=Met=methionine F=Phe=phenylalanine P=Pro=proline S=Ser=serine T=Thr=threonine W=Trp=tryptophan Y=Tyr=tyrosine V=Val=valine

The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

Example 1

Selected peptides derived from the keratin consensus sequence were chemically synthesized and used to demonstrate the bioactivity of the peptides. Normal human adult dermal fibroblasts were cultured in fibroblast growth medium (Clonetics™/BioWhittaker, San Diego, Calif., USA). Passage 5 cells were seeded into wells of 96 well plates at 5×103 cells/well. Test peptide solutions were prepared at approximately 1.5 mg/ml in sterile water. Small volumes of 0.1N NH4OH were added dropwise to peptide the peptide solutions to completely solubilize the peptides as recommended by the manufacturer (New England Peptide, Inc., Fitchburg, Miss., USA). The volume of NH4OH added to the solution was recorded and used to adjust beginning concentration. Solutions were serially diluted in fibroblast culture medium from 100-0.001 μg/ml, then added to the cells and cultured for 5 days. At day 3, test and control media were removed from each well by vacuum and replaced with fresh test or control solutions. Samples were evaluated in 4 replicate wells. Note in each plate, wells were selected at random to be used as baseline controls to account for any variation in cell seeding between plates. After 5 days, cell proliferation was assessed spectrophotometrically using the Cell Titer96® Cell Proliferation Assay (Promega Corp., Madison, Wis., USA). Absorbance values were normalized to baseline controls and expressed as percent increased (positive values) or decreased (negative values) proliferation.

Mitogenic Effects of 19 Peptides on Human Fibroblasts in Culture for 5 Days Peptides for Cell Culture Studies concentration (ug/mL) Peptide Acidity MW 100 10 1 0.1 0.01 0.001 H2N-VEVDAA- acidic 2x 602 −9.5% −1.3% −4.7% −9.0% 2.3% 11.0% OH H2N-SPLGD- acidic 1x 487 −4.3% −1.2% 1.5% −4.2% 1.7% 11.8% OH H2N-LGDRL- acid/base 572 −3.8% −3.1% −4.8% 0.6% 0.0% 10.3% OH H2N-DLNRVL- acid/base 728 −1.2% −3.5% −2.8% −0.4% 11.5% 14.4% OH H2N-DLNQ- acidic 1x 488 −3.6% −0.7% −0.8% 2.6% 8.9% 15.9% OH H2N- acidic 1x 701 −5.5% 5.5% 0.7% 1.2% 7.9% 10.4% VDTAPTV-OH H2N-AAPTV- neutral 457 −5.9% −5.9% 2.8% 0.3% −0.2% 11.0% OH H2N-AAPTVD- acidic 1x 572 1.6% −2.0% 1.7% −1.1% 7.9% 11.6% OH H2N-DAAPTV- acidic 1x 572 −2.7% −6.1% 3.5% 7.5% 9.5% −3.0% OH H2N-TAPTV- neutral 487 0.7% −2.7% 8.2% 9.4% −1.2% 5.2% OH H2N-DTAPTV- acidic 1x 602 7.6% 2.2% 2.9% 6.7% 2.5% 3.2% OH H2N-TAPTVD- acidic 1x 602 6.9% 4.0% 2.1% −0.5% −0.9% 0.3% OH H2N- acidic 1x 728 6.7% 8.1% −6.0% 2.8% 3.9% 1.2% APTVDLN-OH H2N-VDTAPT- acidic 1x 602 4.4% −0.1% 2.5% 6.8% 4.2% 9.0% OH H2N- acidic 2x 701 4.1% 16.5% 7.1% 5.4% 8.9% 6.5% EVDAAPT-OH H2N-VDAAPT- acidic 1x 572 13.3% 6.2% 4.5% −3.6% 2.9% 1.6% OH H2N-RLNVEV- acid/base 728 10.6% 6.4% 1.9% −4.3% −6.0% −2.6% OH H2N-LNVEV- acidic 1x 572 13.9% 15.9% −11.4% −10.8% 0.9% −1.0% OH H2N-TLRSP- basic 1x 572 18.8% 14.7% 6.6% 7.7% 1.9% 4.7% OH Fibroblast GF 70.3%

It is understood that the test concentrations may be further optimized to determine the optimal concentration of each peptide formulation for either activation or inhibition of cell proliferation. However, the data contained in this example demonstrate the activity of the peptide compositions in the fibroblast assay. The test data further demonstrates like activity for peptides that contain thematic amino acid sequences LGD, DLN, APTV, SEQ ID NO:67, or LNVEV, SEQ ID NO:118.

Numerous advantages of the invention covered by this document have been set forth in the foregoing description. It will be understood, however, that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of reagents, concentrations, and step order, and still fall within the spirit and scope of the invention. 

1-39. (canceled)
 40. A bioactive peptide having an amino acid sequence consisting of from 4 to 24 contiguous amino acids of any of SEQ ID NOS:1-32.
 41. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 24 contiguous amino acids of any of SEQ ID NOS:1-32.
 42. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 23 contiguous amino acids of any of SEQ ID NOS:1-32.
 43. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 22 contiguous amino acids of any of SEQ ID NOS:1-32.
 44. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 21 contiguous amino acids of any of SEQ ID NOS:1-32.
 45. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 20 contiguous amino acids of any of SEQ ID NOS:1-32.
 46. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 19 contiguous amino acids of any of SEQ ID NOS:1-32.
 47. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 18 contiguous amino acids of any of SEQ ID NOS:1-32.
 48. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 17 contiguous amino acids of any of SEQ ID NOS:1-32.
 49. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 16 contiguous amino acids of any of SEQ ID NOS:1-32.
 50. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 15 contiguous amino acids of any of SEQ ID NOS:1-32.
 51. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 14 contiguous amino acids of any of SEQ ID NOS:1-32.
 52. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 13 contiguous amino acids of any of SEQ ID NOS:1-32.
 53. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 12 contiguous amino acids of any of SEQ ID NOS:1-32.
 54. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 11 contiguous amino acids of any of SEQ ID NOS:1-32.
 55. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 10 contiguous amino acids of any of SEQ ID NOS:1-32.
 56. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 9 contiguous amino acids of any of SEQ ID NOS:1-32.
 57. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 8 contiguous amino acids of any of SEQ ID NOS:1-32.
 58. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 7 contiguous amino acids of any of SEQ ID NOS:1-32.
 59. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 6 contiguous amino acids of any of SEQ ID NOS:1-32.
 60. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 5 contiguous amino acids of any of SEQ ID NOS:1-32.
 61. The bioactive peptide of claim 40, wherein the amino acid sequence consists of 4 contiguous amino acids of any of SEQ ID NOS:1-32.
 62. The bioactive peptide of claim 40, selected from DLNQ, SEQ ID NO:71, SPLGD, SEQ ID NO:111, LGDRL, SEQ ID NO:114, LNVEV, SEQ ID NO:118, AAPTV, SEQ ID NO:128, TAPTV, SEQ ID NO:129, NTLRSP, SEQ ID NO:162 RLNVEV, SEQ ID NO:184, VEVDAA, SEQ ID NO:188, VDAAPT, SEQ ID NO:192, VDTAPT, SEQ ID NO:193, DTAPTV, SEQ ID NO:195, AAPTVD, SEQ ID NO:196, TAPTVD, SEQ ID NO:197, DLNRVL, SEQ ID NO:205, EVDAAPT, SEQ ID NO:263, VDTAPTV, SEQ ID NO:266, DAAPTVD, SEQ ID NO:267, and APTVDLN, SEQ ID NO:271.
 63. The bioactive peptide of claim 40, selected from APTV, SEQ ID NO:67 and LNVEV, SEQ ID NO:118.
 64. A composition in the form of a powder, lotion, hydrogel, oil, emulsion, paste, polish or cream, wherein the compositions comprises the bioactive peptide of claim 40 in combination with a carrier.
 65. A wound dressing comprising the bioactive peptide of claim
 40. 66. The wound dressing of claim 65, wherein the wound dressing is a sheet comprising a keratin derived product.
 67. The wound dressing of claim 65, further defined as an adhesive bandage.
 68. A tissue engineering scaffold comprising the bioactive peptide of claim
 40. 69. The tissue engineering scaffold of claim 68, wherein the tissue engineering scaffold comprises an insoluble material at least a part of which is obtained from a keratin product.
 70. A composition in the form of a hydrogel, wherein the bioactive peptide of claim 40 is contained in or associated with the hydrogel.
 71. The composition of claim 70 wherein the hydrogel comprises a keratin derived hydrogel.
 72. A composition for topical application to skin of a human or animal subject, said composition comprising the bioactive peptide of claim 40, contained in a lotion, gel, paste, cream, or aqueous solution.
 73. The composition of claim 72, for topical application to damaged epithelial tissue.
 74. The composition of claim 73, wherein the epithelial tissue is skin, nasal, oral, gastro-intestinal, anal, vaginal, ear, eye, lung, or urogenital epithelial tissue.
 75. The composition of claim 73, wherein the damaged epithelial tissue comprises a wound, a rash, diaper rash, a burn, a sunburn, a cut, an abrasion, a puncture, a sore, a bedsore, an ulcer, or wrinkled skin.
 76. The composition of claim 72, wherein the peptide concentration is from about 100 μg/ml to about 1×10⁻⁶ μg/ml.
 77. A composition for cosmetic application to skin comprising the bioactive peptide of claim 40 combined with a carrier.
 78. The composition of claim 77, wherein the composition is a moisturizer, a deodorant, an anti-aging/skin repair preparation, a cleanser, a toner, an eye care composition, a lip care composition, a fingernail care composition, a toenail care composition, a scalp care composition, a sun care composition, a hand care composition, or a body care composition.
 79. The composition of claim 77, wherein the composition is an after-care product for a skin insult.
 80. The composition of claim 79, wherein the skin insult is a chemical peel, sunburn, depilatory irritation, razor-shaving nick, an abrasion, or scalp irritation from hair treatment
 81. The composition of claim 77, wherein the composition is a water based make up.
 82. The composition of claim 77, wherein the composition is a hair care product.
 83. The composition of claim 82, wherein the product is a shampoo or hair conditioner.
 84. A wound dressing comprising the bioactive peptide of claim 40 contained in, or adhered to a sheet, film or fabric dressing.
 85. The wound dressing of claim 84, wherein the dressing comprises a keratin derivative.
 86. The wound dressing of claim 84, wherein said wound dressing is an adhesive bandage.
 87. The wound dressing of claim 84, wherein the dressing comprises wool or cotton fabric.
 88. The wound dressing of claim 84, wherein the dressing is a woven keratin sheet.
 89. The wound dressing of claim 84, wherein the dressing is a non-woven sheet or film comprising a water insoluble keratin.
 90. A cell growth scaffold comprising a keratin derived sheet material, porous material or hydrogel, and further comprising the bioactive peptide of claim 40 contained in, or non-covalently adhered thereto.
 91. The cell growth scaffold of claim 90, further defined as a spinal implant, a bone growth scaffold, a scaffold for growth of epithelial tissue, a bandage, a non-woven sheet or a woven sheet.
 92. The cell growth scaffold of claim 91, wherein the non-woven or woven sheets comprise wool pads, woven keratin, keratin bonded to polymer sheets, or cross-linked keratin.
 93. The cell growth scaffold of claim 90, further comprising an envelope containing the peptides.
 94. The cell growth scaffold of claim 90, comprising peptides bonded or adhered to the surface of a metal, silicone or polymer implant.
 95. A bioactive peptide having an amino acid sequence consisting of from 4 to 24 contiguous amino acids of any of SEQ ID NOS:1-32, and in which the N-terminal α-amine group is acetylated.
 96. A bioactive peptide having an amino acid sequence consisting of from 4 to 24 contiguous amino acids of any of SEQ ID NOS:1-32, and in which the C-terminal α-carboxy group is a carboxamide.
 97. A method of increasing cellular proliferation comprising contacting skin, bone, or connective tissue cells with the bioactive peptide of claim
 40. 98. The method of claim 100, wherein the cells are fibroblasts, keratinocytes, or osteoblasts. 